inhibin, 316
inhibitory factors, 340
innate immunity, 390
inorganic substances as drugs and targets, 532–537
inosiplex, 397, 398
inositol triphosphate diacylglycerol receptor
system, 95
insecticides, acetylcholinesterase inhibitors and,
490–491
insulin, 310, 311, 364–370
biochemical effect, 365
isophane, 366
lente, 366, 367
lispro, 366, 367
ultralente, 366, 367
zinc, 366, 367
insulin binding, 365
insulin preparations, 366
insulin secretagogs, 367
intercalating agents, 443–446
interferons, 396, 397, 398
interleukin-1, 520
interleukins, 398, 400
intermittent claudication, 379
interstitial cell-stimulating hormone, 346
intracranial pressure, increased, 528
intrathecal, 202
intrinsic factor, 508
intron, 442
iodoform reaction, 178
iodothyronines, 360–363
ionic bonds, drug receptor interactions, 71
ionization constant, drugs, 14
ionophore antibiotics, 569
iproniazid, 498
irbesartan, 376
irinotecan, 452
irritable bowel syndrome, 233, 289
ischemia, definition, 317
islets of Langerhans, 311, 364
isomerases, 468
isoniazid, 18, 498
isonicotinylhydrazide, 498
isoprene rule of Ruzicka, 474
isoproterenol, 14, 231
isoreceptors, 339
isosorbide dinitrate, 296
isotretinoin, 509
isoxazole metabolism, 152
isradipine, 428
itraconazole, 584
ivermectin, 588
kainate, 284
kanamycin, 14, 574
Kearns-Sayre syndrome, 400
keratins, 467
keratocyte growth factor, 400, 401
ketanserin, 256
ketobemidones, 357
ketoconazole, 18, 583
ketoprofen, 525
ketorolac, 525
kidney, 311
kidney peptide hormones, 371–376
Kier-Hall indices, 143
kinase C, 94–96
kinase inhibitors, 457, 499–500
kinases as targets, 499–500
Korsakoff syndrome, 513labetalol, 102, 235
lactose, 476
lamivudine, 554
lamotrigine, 279, 287, 422
lanantoside, 438
large neutral amino acid transporter, 433
lazaroids, 411
LDL, 318
lead poisoning, 594
lecithins, 472, 529
leflunomide, 393
legionnaire’s disease, 576
leishmaniasis, 584
lenticular nucleus, 200
leprosy, 395, 579
letrozole, 458
Leu-enkephalin, 351
leukemia, 460, 462
leukocytes, 335, 387, 390
leukotriene antagonists, 527
leukotriene biosynthesis, 521
leukotrienes, 473, 519
leuprolide, 342
levallorphan, 359
levamisole, 397
levodopa, 14, 18
levonorgestrel, 326, 327
levorphanol, 138, 356
levothyroxine, 362
levotrotatory, 475
levulose, 476
LH, 315, 316, 324, 342, 346
LHRH, 342–343
libraries, molecular, 123
lice, 585
lidocaine, 14, 16, 18, 102, 155, 417, 531
ligand gated ion channels, 92, 412
ligases, 468
lincomycins, 576INDEX 639