Panic Disorder:Examples● Trazodone C/4 – 9 Nefazodone*Generic Name75 m g /d ay. M ay i nc re a s e do s e i n i nc reme nt s of up t o 75 m g /d ay at intervals of at least 7 days to a maximum of 225 mg/day. 37.5 mg/day for 7 days. After 7 days, increase dosage to (^) ANTAGONISTS/ REUPTAKE INHIBITORS (SARIs)CHEMICAL CLASS: SEROTONIN-2 Categories/Pregnancy C/2–4 Half-life (hr) PO: ●Unlabeled uses:●●●Indications●● Extended-release caps:Migraine Insomniabia with panic and agorapho-Depression DepressionpreventionattacksAggressive behaviorPanic disorder Not well Therapeutic-Plasma Level Ranges (ng/ml)800–1600establishedAntidepressants Initial dosage: Tabs: 50, 100, Forms (mg) Available Tabs: 50, 100, 150, 200, 250150, 300 ●^433
2506_Ch26_417-446.indd 1433 2506 Ch 26 417 - 446 .indd 2 weeks of use of, MAOIs • Acute phase of myocardial infarctionUse Cautiously in:Actionestablished) • Children (safety not established) • Patients with suicidal ideation • Patients with hepatic, renal, or cardiovascular disease • Elderly and debilitated patients* Bristol-Myers Squibb voluntarily removed their brand of nefazodone (Serzone) Contraindications and PrecautionsContraindicated in: 1 ● with terfenadine, astemizole, cisapride, pimozide, carbamazepine, or triazolam (nefazodone) • Patients who were withdrawn because of liver injury (nefazodone) • Concomitant use with, or within 4 various other manufacturers.from the market in 2004. The generic equivalent is currently available through 3 Trazodone inhibits neuronal reuptake of serotonin; nefazo-rine and acts as an antagonist at central 5-HTdone inhibits neuronal reuptake of serotonin and norepineph- 3 • Pregnancy and lactation (safety not • Hypersensitivity • Coadministration^2 receptors. 1 10/1/10 9:39:23 AM 0 / 1 / 10 9 : 39 : 23 AM
