Science - USA (2021-11-12)

SCIENCE science.org CREDITS: (DATA U.S. CENTERS FOR DISEASE CONTROL AND PREVENTION; (PHOTO CLIMEWORKS/COVER IMAGES/AP IMAGES tra ...

molecules and Xe- and CO-tip models. Excel- lent agreement between thewB97X-V inter- action energies and the experimental data r ...

NEWS | IN BRIEF science.org SCIENCE PHOTO: PAUL TAFFOREAU greater than other diseases for which vaccination is now routine. Surv ...

NEURODEGENERATION CD4 + T cells contribute to neurodegeneration in Lewy body dementia David Gate1,2,3, Emma Tapp2,3, Olivia Leve ...

PHOTO: RORY DOYLE/ THE NEW YORK TIMES /REDUX PICTURES SCIENCE science.org 12 NOVEMBER 2021 • VOL 374 ISSUE 6569 799 L ast week’s ...

clonally expanded (i.e., antigen-specific) cells were distinct in PD-DLB. To assess clonal ex- pansion, we performed single-cell ...

GRAPHIC: V. ALTOUNIAN/ SCIENCE science.org SCIENCE lighting it only for people at increased risk of severe COVID-19. Pfizer’s pi ...

a marker of proinflammatory interleukin-17 (IL-17)–producing [T helper 17 (TH17)] mem- ory CD4+T cells ( 17 , 18 ) (Fig. 2F and ...

CREDITS: (ILLUSTRATION C. BICKEL/ SCIENCE ; (PHOTO STR/NURPHOTO/GETTY IMAGES SCIENCE science.org 12 NOVEMBER 2021 • VOL 374 ISSU ...

on PDD meninges, which revealed meningeal CD3+CXCR4+cells (fig. S7A). We noted locali- zation of the CXCR4 ligand, C-X-C motif c ...

ILLUSTRATION: C. BICKEL/ SCIENCE 802 12 NOVEMBER 2021 • VOL 374 ISSUE 6569 I n 2000, the U.S. astronomy “decadal survey”—a prior ...

1 (ACTG1) andactin beta(ACTB) (Fig. 5D), which regulate cytoskeletal control of antigen- dependent T cell activation ( 20 ). We ...

SCIENCE science.org 12 NOVEMBER 2021 • VOL 374 ISSUE 6569 803 scope focusing on habitable exoplanets, and observatories sensitiv ...

SCIENCEscience.org 12 NOVEMBER 2021¥VOL 374 ISSUE 6569 873 Fig. 5. Stimulation of LBD T cells witha-synuclein promotesIL-17A exp ...

ILLUSTRATION: V. ALTOUNIAN/ SCIENCE 804 12 NOVEMBER 2021 • VOL 374 ISSUE 6569 science.org SCIENCE T he artificial intelligence ( ...

that promoted expression ofIL17A, a pro- inflammatory cytokine involved in autoimmune diseases ( 21 ). In animal models of neuro ...

PHOTO: CHANG HYON HA SCIENCE science.org 12 NOVEMBER 2021 • VOL 374 ISSUE 6569 805 T he drama of the world’s most con- troversia ...

and remains in one cell in regions 2b to 3, where it forms distinct foci in the cytoplasm (Fig. 2, A and A′). This cell will bec ...

NEWS FEATURES PACKED WITH PURPOSE After a sea journey to its launch site in French Guiana, the James Webb Space Telescope was ex ...

distributed more homogeneously (Fig. 3, B and C, and movies S3 and S4). Patronin is therefore required for MTOC formation in the ...