Science - USA (2021-12-17)
complex, meaning that they are not directed, not acyclic, or not free of internal source and sink nodes. Mapping accuracy result ...
Fine-tuning SVs with frequencies SVs in the input catalogs may contain errors. When multiple alleles co-occur at an SV site, we ...
replicated these observations in the high- coverage 1000 Genomes Project dataset ( 31 ). Here, again, the PCA of the allele coun ...
an SV-eQTL, adjustedp= 0.008). As expected, SV-eQTLs were strongly enriched in coding, intronic, promoter, untranslated, and reg ...
using default Giraffe and VG-MAP. For com- parison,wemappedthesamereadstoGRCh38 with BWA-MEM. Genotyping accuracy We compared th ...
M. Fagnyet al., Exploring regulation in tissues with eQTL networks.Proc. Natl. Acad. Sci. U.S.A. 114 , E7841–E7850 (2017). doi: ...
Publishyourresearch intheSciencefamilyofjournals TheSciencefamilyofjournals(Science, Science Advances,ScienceImmunology, Science ...
RESEARCH ARTICLE SUMMARY ◥ CANCER IMMUNOLOGY Pan-cancer single cell landscape of tumor-infiltrating T cells Liangtao Zheng†, Shi ...
RESEARCH ARTICLE ◥ CANCER IMMUNOLOGY Pan-cancer single-cell landscape of tumor-infiltrating T cells Liangtao Zheng^1 †, Shishang ...
Zhenget al.,Science 374 , eabe6474 (2021) 17 December 2021 2 of 11 Fig. 1. Pan-cancer T cell profile at the single-cell resoluti ...
indicating that this metacluster contained both MAIT and non-MAIT Tc17 cells (desig- nated Tc17 hereafter). ThecompositionsofTce ...
Zhenget al.,Science 374 , eabe6474 (2021) 17 December 2021 4 of 11 Fig. 2. Heterogeneity and dynamics of CD8+exhausted T cells.( ...
T cells (figs. S18). Because of the scarcity of these two cell populations, it remains to be seen whetherTCF7+Texcells were deri ...
generalized additive model) (Fig. 3B). Also, the TFRUNX3(runt-related transcription factor 3) exhibited elevated expression at a ...
target genes, most of which were also signa- ture genes ofTNFRSF9+Tregcells, including TNFRSF4,TNFRSF9,ID3(inhibitor of DNA bind ...
the head and neck squamous cell carcinoma showing the highest median value (2.63%), a subset of melanoma samples could reach a f ...
frequencies. This association might be medi- ated by theFAT1-Hippo-YAP1 (yes-associated protein 1) pathway dysfunction in cancer ...
from single-cell suspensions. The libraries of single-cell transcriptome and single-cell TCR were prepared by means of a 10x Chr ...
ACKNOWLEDGMENTS We thank Y. Yang, B. Zhang, Y. Gao, Y. Li, M. Gao, K. Wang, D. Lin, L. Zhou, and L. Jiang for clinical sample co ...
GOLDOPENACCESS,DIGITAL,ANDFREETO ALLREADERS AsAAAS’s firstmultidisciplinary, openaccessjournal,ScienceAdvancespublishes research ...
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