Textbook of Personalized Medicine - Second Edition [2015]

285 Proteomics of Brain Cancer Protein biomarkers of brain tumors have the potential for clinical usefulness to predict effi cac ...

286 glioma stem-like cells, including CD133 and nestin. Finally, a multigene predictor of outcome in GBM was identifi ed, which ...

287 Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) tumor suppressor is frequently phosphorylated at a conserved ...

288 growth, whatever their histological subtypes. The radiological tumor growth is eas- ily quantifi ed by measuring the evoluti ...

289 Clinical implementation of these results is expected to greatly improve routine glioma diagnostics and will enable a patient ...

290 Personalized Therapy of Medulloblastomas Medulloblastoma is a malignant tumor of the cerebellum usually diagnosed in chil- d ...

291 Personalized Management of Meningiomas Meningiomas are the most common primary brain tumors and affect ~170,000 patients in ...

292 and 1p/19q co-deletion (predictive) are currently routinely used for evaluation of glioma patients by clinicians in the US a ...

293 its many downstream players, such as PTEN or AKT. There is a lot of crosstalk between the PI3K pathway and other pathways, a ...

294 Gene Expression Plus Conventional Predictors of Breast Cancer In a retrospective study, researchers combined conventional pr ...

295 EGFR and the ER are the most dangerous combination of molecules overproduced in breast cancer. When both are overfunctioning ...

296 amplifi cation of HER2 in breast-cancer cells is associated with better clinical responsiveness to anthracycline-containing ...

297 targeted to chromosome 17 and the HER2/TOP2 amplicon (Yeh et al. 2009 ). Results were 97 % concordant for HER2 status, meeti ...

298 commercial DNA sequencing technologies, but only by laborious, manual research- based methods. Such rearrangements are respo ...

299 fast, reproducible, tissue-sparing, quantitative, automatable, and can be performed from archived (formalin-fi xed, paraffi ...

300 existing pathology tests. This is one important step towards personalized diagnosis and treatment planning based on an integ ...

301 characterization of CTCs could contribute to personalized treatment selection (Toss et al. 2014 ). A clinical study has used ...

302 Despite recent advances in breast cancer therapy, women with similar types of breast cancers may respond very differently to ...

303 et al. 2011 ). Breast cancer treatment sensitivity was predicted using combination of signatures for (1) sensitivity to endo ...

304 distinct gene expression profi les and clinical features, and they comprise the majority of BRCA1-associated tumors. Global ...