Science - USA (2022-01-14)
an increase in median or maxi- mal life span. —LBR Aging Cell 10.1111/acel.13488 (2021). NEUROSCIENCE The dance of sleep Because ...
157-B 14 JANUARY 2022 • VOL 375 ISSUE 6577 science.org SCIENCE RESEARCH CELL BIOLOGY Animal-free research products Cell culture ...
SCIENCE science.org 14 JANUARY 2022 • VOL 375 ISSUE 6577 157-C RESEARCH gravitational interaction with a large mass (see the Per ...
REVIEW SUMMARY ◥ CANCER CDK4 and CDK6 kinases: From basic science to cancer therapy Anne Fassl, Yan Geng, Piotr Sicinski* BACKGR ...
REVIEW ◥ CANCER CDK4 and CDK6 kinases: From basic science to cancer therapy Anne Fassl, Yan Geng, Piotr Sicinski* Cyclin-depende ...
protein with a half-life of less than 30 min. At the end of G 1 phase, cyclin D1 is phosphoryl- ated at Thr^286 by GSK3b( 15 ). ...
and other cellular proteins and promotes cell cycle progression. Cyclin D1–CDK4/6 directly phosphorylates, stabilizes, and activ ...
mechanisms in the context of human tumors is unclear and requires further study. Mechanism of action of CDK4/6 inhibitors Three ...
radiation ( 63 ) or cisplatin ( 68 ). The synergism with platinum-based chemotherapy was attributed to the observation that upon ...
inhibitors and PARP inhibitors in PDX-derived cell lines ( 100 ). Such synergy was also reported for ovarian cancer cells ( 101 ...
underlies some cases of CDK4/6 inhibitor resist- ance (see below) ( 111 ), stimulation of lysosomo- genesis by CDK4/6 inhibitors ...
Fasslet al.,Science 375 , eabc1495 (2022) 14 January 2022 8 of 19 Table 3. Major past clinical trials with CDK4/6 inhibitors. ER ...
Fasslet al.,Science 375 , eabc1495 (2022) 14 January 2022 9 of 19 CDK4/6inhibitor Trial name Trial details Treatment Patients Ou ...
Fasslet al.,Science 375 , eabc1495 (2022) 14 January 2022 10 of 19 CDK4/6inhibitor Trial name Trial details Treatment Patients O ...
letrozole or anastrozole, or the estrogen receptor antagonist fulvestrant) for treatment of advanced/metastatic HR+/HER2–breast ...
Fasslet al.,Science 375 , eabc1495 (2022) 14 January 2022 12 of 19 Table 4. Ongoing clinical trials testing new combinations wit ...
Fasslet al.,Science 375 , eabc1495 (2022) 14 January 2022 13 of 19 Additional target Inhibitor Immune checkpoint inhibitor Tumor ...
Fasslet al.,Science 375 , eabc1495 (2022) 14 January 2022 14 of 19 Additional target Inhibitor Immune checkpoint inhibitor Tumor ...
combination with CDK4/6 inhibitors blocked proliferation of CDK4/6 inhibitor–resistant cancer cells ( 111 , 141 , 158 – 161 ). R ...
revealed that lysosomotropic agents that re- verse the lysosomal sequestration (such as chloroquine, azithromycin, or siramesine ...
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