Science - USA (2022-01-14)
escape lysosomal sequestration and may be ef- ficacious against resistant cancer types such as TNBC. Degrader compounds, which i ...
cancer: Key mechanisms of response and failure.Oncogene 29 , 4018–4032 (2010). doi:10.1038/onc.2010.154; pmid: 20473330 J. Luka ...
A. Fasslet al., Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhib ...
Publishyourresearch intheSciencefamilyofjournals TheSciencefamilyofjournals(Science, Science Advances,ScienceImmunology, Science ...
RESEARCH ARTICLE SUMMARY ◥ CELL BIOLOGY Mitochondria shed their outer membrane in response to infection-induced stress Xianhe Li ...
RESEARCH ARTICLE ◥ CELL BIOLOGY Mitochondria shed their outer membrane in response to infection-induced stress Xianhe Li^1 , Jul ...
The parasite effector TgMAF1 is required for SPOT formation and the depletion of host mitochondrial proteins How doesToxoplasmai ...
mediator of mitophagy, nor the loss of the essential autophagy geneAtg7prevented the Toxoplasma-induced reduction in MFN1 and MF ...
Liet al.,Science 375 , eabi4343 (2022) 14 January 2022 4 of 10 G H (^001234) 50 100 150 pixel intensity (a.u.) (^001234) 20 40 6 ...
TgMAF1-dependent manner (fig. S9, A and B). Opposite to HSP90 however, concen- trations of 11 of the 22 detected SLC25 pro- tein ...
but not depolarization of the MMP, inhibition of the IMS pathway, or clogging of the TOM40 channel. Whether mitochondria are phy ...
the OMM that can have toxic consequences for the cell (fig. S18) ( 4 , 37 ). In the context of in- fection, however, the constan ...
larger SPOTs that range up to 10mmindia- meter, are also SNX9-dependent, and vary in substructure and shape. What factors dictat ...
Whether other pathogen effector proteins coopt host import receptors for their func- tion, analogous to how TgMAF1 exploits host ...
REFERENCES AND NOTES L. Pernas, L. Scorrano, Mito-morphosis: Mitochondrial fusion, fission, and cristae remodeling as key media ...
RESEARCH ARTICLE SUMMARY ◥ CORONAVIRUS Impact of community masking on COVID-19: A cluster-randomized trial in Bangladesh Jason A ...
RESEARCH ARTICLE ◥ CORONAVIRUS Impact of community masking on COVID-19: A cluster-randomized trial in Bangladesh Jason Abaluck^1 ...
nose and 6% wearing masks improperly. An August 2020 phone survey in rural Kenya found that although 88% of respondents claim to ...
Our intervention reduced symptomatic seroprevalence Among the 336,010 participants who com- pleted symptom surveys, 27,160 (8.1% ...
Fever and cough. Any three of the following: fever; cough; general weakness and/or fatigue; headache; muscle aches; sore throat ...
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