Science - USA (2022-02-18)

previously been implicated in TORC1 signal- ing ( 6 , 26 ). For this analysis, we replenished aspartate and glutamate concentrat ...

thiolation, the generation of hydrogen sul- fide, the regulation of hypoxia-inducible factor (HIF), and its antioxidant function ...

instar stage. They were then transferred on thesamefoodtypesupplementedwith0.5% weight/volume erioglaucine disodium salt (Sigma- ...

deproteinized by the addition of 25ml of 12% sulfosalicylic acid. Protein-free supernatants were kept frozen at–80°C until analy ...

W. C. Rose, R. L. Wixom, The amino acid requirements of man. 13. The sparing effect of cystine on the methionine requirement.J. ...

GOLDOPENACCESS,DIGITAL,ANDFREETO ALLREADERS AsAAAS’s firstmultidisciplinary, openaccessjournal,ScienceAdvancespublishes research ...

RESEARCH ARTICLE SUMMARY ◥ BLOOD-BRAIN BARRIER Engineered Wnt ligands enable blood-brain barrier repair in neurological disorder ...

RESEARCH ARTICLE ◥ BLOOD-BRAIN BARRIER Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders Maud M ...

The near-uniform competence of Fz iso- forms for Gpr124/Reck-dependent Wnt7a/b signaling reveals that these ligands lose their c ...

in site 2 contacts did not affect Gpr124/Reck- mediated signaling while reducing Fz5 signal- ingbymorethan50%(fig.S5).BothWnt7aC ...

Brainwide delivery of Gpr124/Reck agonists in mice We next evaluated Gpr124/Reck agonists as BBB-protective agents in mammals. T ...

(Fig. 4B, asterisks). The distribution of the lig- ands, and hence their potential activity, likely reflects the expression patt ...

Although the ectopic Wnt7a activities did not result in obvious behavioral defects in adult mice (fig. S15), gene delivery of Wn ...

brain tumors ( 12 , 14 , 32 , 33 ). Two days after orthotopic implantation of 1 × 10^5 GL261 tu- mor cells into the C57BL/6 mous ...

more compact and smoother distribution of laminin (Fig. 5D). Cell densities were com- parable in AAV-EGFP and AAV-K190A tumors ( ...

of interaction with the widely expressed Fz receptors. In contrast to Wnt7a, the uncovered Gpr124/ Reck agonists were well toler ...

approaches, we here repurposed a key devel- opmental BBB-inductive signal, acting at the top of the differentiation cascade that ...

Cancer Cell 33 , 874–889.e7 (2018). doi:10.1016/ j.ccell.2018.03.020; pmid: 29681511 A. Ben-Zviet al., Mfsd2a is critical for t ...

Yes, I would like more informationaboutjoiningthe AAAS 1848 Society. PLEASECONTACT MEAT: Name: Address: City: State: Zip code: C ...

RESEARCH ARTICLE SUMMARY ◥ STRUCTURAL BIOLOGY Structures from intact myofibrils reveal mechanism of thin filament regulation thr ...