Science - USA (2022-02-18)

mean of serum concentrations in SELMA pregnant women. The tested dose range was adjusted to the experimental models to ac- commo ...

continuous exposure that occurs in vivo during progenitor expansion ( 26 ); and (ii) three-dimensional (3D) cortical brain organ ...

exposure to be extended from pluripotency through an intermediate stage of corticogenesis (day 50), a stage that features a part ...

this network to infer the transcription factors (TFs) whose altered activity (inferred from their downstream output and hence ag ...

exposure (100X:P= 0.0006; 1000X:P= 0.0033) (Figs. 1C and 5D and table S6). To confirm the impact of the mixture on the thyroid s ...

respectively) (fig. S6, B and C). In line with this observation, although MIX N and BPA shared bdnfas a common dysregulated targ ...

exposure and language delay in children, on the basis of the original hypothesis on the di- rection of the outcome associated wi ...

targets: (i) those for which evidence of hap- loinsufficiency as disease mechanism was concordant with the down-regulation of th ...

EDC exposure For EDC chemical exposure of fetal progeni- tors, cells were seeded in six-well plates. When 70 to 80% confluency w ...

used for the larval mobility assay or collected for gene expression analysis. RNA extraction and qPCR analysis in D. rerio Poole ...

H. Guoet al., Inherited and multiple de novo mutations in autism/developmental delay risk genes suggest a multifactorial model. ...

Environ. Int. 85 , 27–39 (2015). doi:10.1016/ j.envint.2015.08.005; pmid: 26313703 K. Larssonet al., Exposure determinants of p ...

Where Science Gets Social. AAAS’ MemberCommunityisaone-stopdestinationforscientists and STEM enthusiasts alike. It’s“WhereScienc ...

RESEARCH ARTICLE SUMMARY ◥ CELL BIOLOGY Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting ...

RESEARCH ARTICLE ◥ CELL BIOLOGY Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting Patrick ...

(fig. S3B). Depletion of PC also suppressed TORC1 reactivation during fasting (Fig. 1D), supporting the functional link between ...

larvae showed similar abundance of cysteine, likely reflecting dietary intake as the main source of cysteine. By contrast, in fa ...

fasteddCTNSmutant animals (fig. S8C), sug- gesting that cysteine from lysosomal origin limits the activity of the trans-sulfurat ...

or low concentrations of cysteine (which did not affect development of control animals) de- creased the starvation sensitivity o ...

B and C, and fig. S13, A and B). In addition, dCTNSoverexpression was sufficient to de- plete triglyceride stores in fed animals ...