David and Goliath: Underdogs, Misfits, and the Art of Battling Giants

strange smell, his first whiff of tear gas. Then he beckoned Farmer out of the car and strode into the mob. Farmer followed, “sc ...

one terrible moment, and the injuries do not heal as quickly as a bruise or a wound. But what happens to children whose worst fe ...

rest of the way to jail, where, forbidden to sing or pray, he took a nap.” ...

8. The work that Freireich had done in stopping the bleeding was a breakthrough. It meant that children could now be kept alive ...

only some of a child’s cancer cells. The patient would get better for a week or so. Then the cells that had survived would start ...

This was the world’s authority.” But Frei and Freireich and a companion group at the Roswell Park Memorial Institute in Buffalo ...

from the air while the other drugs attacked from the land and sea. Then Freireich stumbled across a fourth drug, one derived fro ...

So Frei and Freireich went to the NCI’s research oversight board to ask for permission to test all four drugs together: army, na ...

paralyzed. When you get a toxic dose, you end up in coma. Of the first fourteen children we treated, one or two actually died. T ...

diseases like childhood leukemia, so he talked about Hodgkin’s disease in adults. He said that if you have a patient who has wid ...

He had only reluctantly approved the vincristine experiment. He was responsible for what happened on the second floor. If someho ...

drugs were all poisons, Frei argued. But they were poisonous in different ways, which meant that if you were careful with the do ...

the drugs. I had to mix them. I had to inject them. I had to do the blood counts. I had to measure the bleeding. I had to do the ...

The only problem was that the cancer wasn’t gone. A handful of malignant cells was still lurking. One bout of chemotherapy would ...

around, playing football, and I was going to put them in the hospital again and make them sick again. No platelets. No white cel ...

were never given in combination. You gave a second antibiotic only when the first one stopped working. “One of the first things ...

criticism,” DeVita continued. “The clinical associates thought that what he was doing was completely nuts. He carried the weight ...

things over. Did he care what people thought of him? Maybe. But not enough to stop doing what he thought was right.^10 “How Jay ...

been saved by the efforts of Freireich and Frei and the researchers who followed in their footsteps is in the many, many thousan ...

9. Does this mean that Freireich should be glad he had the childhood he had? The answer is plainly no. What he went through as a ...