Science - USA (2022-02-25)

CANCER IMMUNOLOGY Molecular signatures of antitumor neoantigen- reactive T cells from metastatic human cancers Frank J. Lowery^1 ...

C0, represented the most-differentiated TILs within these cell populations (fig. S1E). By integrating 23,712 TCR clonotypes with ...

C7 TILEMstates but were largely absent in C1, C6, and C9 clusters containing tumor- expanded clones (Fig. 1F). By contrast, TCR ...

to prospectively predict antitumor, neoantigen- specific TCRs purely on the basis of TIL tran- scriptomic states. We first teste ...

AUCs > 0.9; table S10, tab 4). These data to- gether suggest that the TIL dysfunctional pro- gram identified here is not limi ...

similar to those of exhausted CD8 cells ob- served in basal and squamous cell carcinoma (Yost.CD8.Exhausted, Pearson’sr= 0.766) ...

the ability of given signatures to call CD4+ NeoTCRs, CD8+NeoTCRs, and public viral TCRs from the archival specimens (training s ...

NIH HPC Biowulf cluster (http://hpc.nih.gov). We also thank NIDAP for providing additional computational support and the CCR Gen ...

Our laser cavity consists of two trans- versely coupled waveguides in a parity-time (PT) symmetric configuration, in which one o ...

that the two supermodes emit with equal inten- sity in both waveguides at either facet. Atz= 0, the relative phaseφbetween the w ...

To intuitively understand the topological nature of this process, one may consider a random superposition of the transverse eige ...

transfer between the two mode profiles at the output ports. The ratios of the field intensities in the two waveguides are equal ...

ANTIBIOTIC RESISTANCE Minimizing treatment-induced emergence of antibiotic resistance in bacterial infections Mathew Stracy1,2, ...

The large number of correctly treated infec- tions that subsequently gained resistance could be caused by three possible mechani ...

early recurrence with gained resistance after treatment of an initially sensitiveE. coliinfec- tion was strongly associated with ...

892 25 FEBRUARY 2022¥VOL 375 ISSUE 6583 science.orgSCIENCE Fig. 3. Personalized, antibiotic-specific predictions of treatment-in ...

a susceptibility-matched antibiotic (136,047 UTIs and 5821 wound infections). Despite all of these cases being treated“correctly ...

A. L. Flores-Mireles, J. N. Walker, M. Caparon, S. J. Hultgren, Nat. Rev. Microbiol. 13 , 269–284 (2015). F. Collin, S. Karkare ...

by bidirectional elaboration of a simple dimeric cyclotryptophan ( 9 , 11 , 12 ). Direct union of com- plex peptide macrocycles ...

successive generation of radical species in close proximity to each other. For the synthesis of (+)-himastatin mono- mer ( 2 ), ...