Science - USA (2022-02-25)

tendency.Neurobiol. Aging 3 , 321–327 (1982). doi:10.1016/ 0197-4580(82)90020-3; pmid: 7170049 B. A. Mander, J. R. Winer, M. P. ...

V.M.D.’s work. G.S. supervised C.C.’s work. L.d.L. supervised the entire project. S.-B.L. prepared figures and wrote the manuscr ...

RESEARCH ARTICLES ◥ PROTEIN TARGETING Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targe ...

840 25 FEBRUARY 2022¥VOL 375 ISSUE 6583 science.orgSCIENCE Fig. 1. Structure of the ribosome¥NAC complex reveals interactions be ...

hydrophobic ER-targeting signals somehow weaken the interaction between the NAC glob- ular domain and the ribosome to allow SRP ...

chain, as evidenced by cross-linking between a residue in the NACbanchor and the ribo- somal protein eL22, whereas a probe in th ...

To address this, we generated the following: (i) a NAC mutant in which the UBA is deleted (dUBA), (ii) a NAC mutant (D205R/N208R ...

ER signal sequence weakens the interactions of NAC’s globular domain with the ribosome. This allows SRP to bind the signal seque ...

STRUCTURAL BIOLOGY Dynamics and mechanism of a light-driven chloride pump Sandra Mous^1 , Guillaume Gotthard1,2, David Ehrenberg ...

similar affinity as chloride [Cl–:Kd= 24 mM; Br–:Kd=10mM( 17 )]. Furthermore, struc- tural studies show that a bromide ion is co ...

( 28 ). We therefore probed the rise and decay of spectroscopic states (Fig. 1B) in crystals by time-resolved absorption spectro ...

to C). The C20 methyl group of the isomerized retinal pushes against Trp^201 ,shiftingitaway by 0.4 Å. Trp^99 shifts by 0.3 Å to ...

that an intermediate state with sodium cap- tured between retinal and helix C could lead to similar kink formation in KR2. InNmH ...

atDt=12.5ms(fig.S18B).Oncethehalidedif- fuses into the Wat^409 position, the transport path- way is occluded by Asp^231 (Fig. 5C ...

ofNmHR (fig. S22D), indicating that the so- dium and chloride transport pathways may partially overlap on the extracellular side ...

NANOMATERIALS Highly stretchable van der Waals thin films for adaptable and breathable electronic membranes Zhuocheng Yan^1 , Do ...

by the Young’s modulus and the membrane thickness following the relationship p^2 4 P^20 1 v^21 E 1 þ 1 v^22 E 2 "# 2 1 = 3 þ p ...

applications usually show worse mechanical properties owing to their specific structural properties, such as chain length, regio ...

other to form broad-area plane-to-plane VDW interfaces with an average of ~3 to 4 nanosheets staggered in a crisscross manner in ...

The ability of a membrane to make a con- formal interface with the surface topography can be determined by bending stiffness ( 2 ...