Science - USA (2022-03-04)

whole RBD deviating by <0.4 Å (Fig. 3B and table S3). We did see local differences at the ACE2-RBD interface: The Omicron RBD ...

1050 4 MARCH 2022¥VOL 375 ISSUE 6584 science.orgSCIENCE Fig. 2. Structure of the ACE2-bound Omicron spike trimer complex and epi ...

the WT SARS-CoV-2 in cell-based models and in a rhesus monkey model ( 20 ). JMB2002 has completed a phase 1 clinical trial in he ...

RBD-RBD interaction and extra interactions in the ACE2-RBD interface, both of which con- tribute to the higher affinity of ACE2 ...

spike RBD in complex with hACE2, EMD-32682 and PDB ID 7WPC for local refined reconstruction of a second Omicron spike RBD in com ...

top strand, E804 and C(+7) form a key base- specific contact, whereas R808, S732, and N735 contact the sugar-phosphate backbone. ...

SCIENCEscience.org 4 MARCH 2022¥VOL 375 ISSUE 6584 1055 Fig. 2. Sequence-specific recognition of BEND3 and the underlying struct ...

observed at around the Mendelian ratio at E3.5 (Fig. 3A), which suggests thatBend3deletion led to embryonic lethality between E3 ...

SCIENCEscience.org 4 MARCH 2022¥VOL 375 ISSUE 6584 1057 Fig. 4.Bend3deletion leads to premature activation of highly occupied bi ...

up-regulated in WT d2 EBs, but 23 and 43% of them became up-regulated in WT d5 and d8 EBs, respectively (Fig. 4F). BEND3 partici ...

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CREDITS: (PHOTO CYRIL RUOSO/MINDEN PICTURES; (ILLUSTRATION C. SMITH/ SCIENCE 4 MARCH 2022 • VOL 375 ISSUE 6584 935 INSIGHTS PERS ...

936 4 MARCH 2022 • VOL 375 ISSUE 6584 science.org SCIENCE ILLUSTRATION: ZOE ASHBRIDGE/UNIVERSITY OF MANCHESTER RESEARCH IN BRIEF ...