Infectious Diseases in Critical Care Medicine

Holloway KP, Rouophael NG, Wells JB, et al. Polymyxin B and doxycycline use in patient with multidrug-resistanceAcinetobacter b ...

29 Antibiotic Kinetics in the Febrile Multiple-System Trauma Patient in Critical Care Donald E. Fry Northwestern University Fein ...

subsequent use of the drug. The clear objective of pharmacokinetic assessment is to provide antibiotic concentrations, which wil ...

Knowledge of theVdandT1/2allows the design of dose and dosage intervals for the antibiotic. If our theoretical drug in Figure 1 ...

elimination via the kidney. Hepatic metabolism may result in the inactivated metabolite being eliminated within the bile. Clearl ...

of drug elimination. It can be anticipated thatT1/2will be reduced. Subsequent organ failure from the ravages of sustained sepsi ...

multiple-injury patient, despite the fact that antibiotics are used for a wide array of indications in these patients. The effec ...

b-lactam alternatives where toxicity concerns are minimized and larger doses can be safely utilized. The data that evaluate othe ...

vancomycin in infected surgical intensive care unit patients. They assumed and documented that theVdof vancomycin was essentiall ...

and identified nearly a doubling of theVdand a prolongedT1/2. They indicated that 2 g every 12 hours still resulted in adequate ...

significance for pathogens with high MIC breakpoints (41). The observation that the quinolone group of antibiotics have very lar ...

drug is cleared in the first half-life, while the amount of drug that is cleared in the third or fourth half-life is relatively ...

virtues of this delivery method (61,62), but evidence to show consistently superior outcomes have been lacking. Studies have suf ...

kidney and liver perfusion and the intrinsic coexistent dysfunction of the kidney or liver. For most antibiotics used in the mul ...

Kieft H, Hoepelman AIM, Knupp CA, et al. Pharmacokinetics of cefepime in patients with the sepsis syndrome. J Antimicrob Chemot ...

Georges B, Conil JM, Cougot P, et al. Cefepime in critically ill patients: continuous infusion vs an intermittent dosing regime ...

30 Antibiotic Therapy in the Penicillin Allergic Patient in Critical Care Burke A. Cunha Infectious Disease Division, Winthrop-U ...

develop a rash, yet others report the reaction to a penicillin antibiotic was limited to a maculopapular rash. Responses to any ...

metronidazole, polymyxin B, vancomycin, quinupristin/dalfopristin, linezolid, daptomycin, quinolones, monobactams, and as previo ...

Table 3 Antibiotics Safe in Penicillin-Allergic Adult Patients in the CCU Clinical Syndrome PCN allergy Non-PCN allergic .Acute ...