Small Animal Dermatology, 3rd edition

APPENDIX B DRUG FORMULARY 813

Thyroid hormone

See Levothyroxine sodiumand Liothyronine.

Thyrotropin-releasinghormone (TRH)

Used to detecthyperthyroidism when T

4

is not elevated.

Adverse effectsuncommon.

Used for diagnosticpurposes.

Injection.

Collect baseline T

, 4

followed by 0.1 mg/kg IV.Collect post-TRH T

4

sample at 4h.

Thyrotropin,thyroid-stimulatinghormone (TSH)(Thytropar, Thyrogen)

Thyroid-stimulatinghormone is used fordiagnostic testing.Stimulates normalsecretion of thyroidhormone.

Adverse reactions rare. Inpeople, allergic reactionshave occurred.

For Thytropar: to preparesolution, add 2 mL NaCIto 10 U vial. Reconstitutedsolutions retain potencyfor 2 weeks at 2–8

◦C.

Consult testing laboratoryfor specific guidelines forthyroid testing. ForThyrogen: reconstitute vialwith 6 mL sterile water.

Old forms(Thytropar) aredifficult to obtain.Human recombinantform (rh TSH)(Thyrogen) contains1.1 mg/vial.

Dog: collect baselinesample, followed by0.1 U/kg IV (maximumdose is 5 U); collectpost-TSH sample at 6h.For human recombinantform: 50–100

μg per dog.

Ticarcillin + clavulanate(Timentin)

Same as ticarcillin, exceptclavulanic acid has beenadded to inhibit bacterialβ-lactamase and increasespectrum. Clavulanatedoes not increase activityagainst

Pseudomonas

,

however.

Same as for ticarcillin.

Same as for ticarcillin.

3 g per vial forinjection.

Dose according to rate forticarcillin.

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)