Cell - 8 September 2016
Figure S2. Immunization of the VH1-2 Mouse Model, Related toFigure 2 (A) Gating strategy for single cell sorting of eOD-GT8-spec ...
Figure S3. Generation and Characterization of the VH1-2/LC Mouse Model, Related toFigure 3 (A) Southern analysis of wild-type ES ...
Figure S4. The Amino Acid Mutations in All Amplified IGHV1-2*02 HCs, Related toFigure 5 The amino acid mutations in all sequence ...
Figure S5. The Amino Acid Mutations in All Amplified IGKV3-2001 LCs, Related toFigure 4 Mutation profiles of IGKV3-2001 LCs ampl ...
(legend on next page) ...
Figure S6. Mutation Profiles of VRC01 Class Antibodies, Related toFigure 5 (A) Alignment of VH1-202 germline sequence with 25 pu ...
Figure S7. Neutralization IC 50 of the 27 IGHV1-202/IGKV3-2001 IgGs Cloned from Stepwise Immunized Mice against Tier II Viruses, ...
Article gdT Cells Support Pancreatic Oncogenesis by Restrainingab T Cell Activation Graphical Abstract Highlights d gdT cells ar ...
Article gd T Cells Support Pancreatic Oncogenesis by Restraining abT Cell Activation Donnele Daley,1,6,7Constantinos Pantelis Za ...
RESULTS ActivatedgdT Cells Are Ubiquitous in Human PDA Immunohistochemical analysis revealed thatgdT cells are widely distribute ...
Figure 1.gdT Cells Are Ubiquitous and Activated in Human PDA (A) Frozen sections of human PDA and normal pancreas were stained u ...
Figure 2.gdT Cells Are Highly Prevalent and Exhibit a Uniquely Activated Phenotype in Murine Invasive PDA (A) C57BL/6-Trdctm1Mal ...
(legend on next page) Cell 166 , 1485–1499, September 8, 2016 1489 ...
PDA-InfiltratinggdT Cells Do Not Have Direct Pro-tumorigenic Effects on Epithelial Cells We hypothesized thatgdT cells may have ...
Figure 4.gdT Cell Deletion Results in Massive CD4+and CD8+T Cell Infiltration and Activation in Invasive PDA (A and B) WT and Tc ...
deletion (Figure 6E). Notably, besides regulatinggdT cell expan- sion and activation, CCR2, CCR5, and CCR6 signaling were necess ...
GM-CSF-recruited MDSCs negate anti-tumor CD8+CTL re- sponses in PDA and promote metastatic progression (Bayne et al., 2012; Conn ...
(legend on next page) 1494 Cell 166 , 1485–1499, September 8, 2016 ...
(Feig et al., 2013). However, a comprehensive understanding of the basis for T cell scarcity and poor immunogenicity in PDA is l ...
(legend on next page) 1496 Cell 166 , 1485–1499, September 8, 2016 ...
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