Cell - 8 September 2016
Supplemental Figures Figure S1. PolyQ Expression Specifically Induces the UPRmtduring Adulthood and Is Specific for Neuronal Q40 ...
Figure S2. Changes in Protein Expression with RNAi to UPRmtComponents, Related toFigure 2 (A) Immunoblot analysis of the polyQ40 ...
Figure S3. Q19 and High Molecular Weight AbSpecies Do Not Associate with Mitochondria and Evaluation of Gene Expression Changes ...
Figure S4. The Effect ofunc-31Signaling Is Specific to the Neurons and Serotonin Specifically Regulates the Cell-Non-Autonomous ...
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Article Dopamine Neuron-Specific Optogenetic Stimulation in Rhesus Macaques Graphical Abstract Highlights d Cell-type-specific p ...
Article Dopamine Neuron-Specific Optogenetic Stimulation in Rhesus Macaques William R. Stauffer,1,3,5,*Armin Lak,1,4Aimei Yang,^ ...
demonstrate that the viral vector mixture achieved highly spe- cific expression of ChR2 in dopamine neurons and that optical sti ...
attached to optical fibers (optrodes) into the midbrain of two awake monkeys (C and D) (Figure S2;STAR Methods). We iden- tified ...
We compared the neural response to reward plus optical stimu- lation with the neural response to reward delivered alone. We obse ...
Crucially, this signal constitutes a possible neural mechanism for the classically observed behavioral preference for dopamine s ...
et al., 1973; Grace and Bunney, 1983; Schultz and Romo, 1987), and juxtacellular labeling (Brischoux et al., 2009), which uses a ...
Received: May 27, 2016 Revised: July 10, 2016 Accepted: August 12, 2016 Published: September 8, 2016 REFERENCES Amemori, K., and ...
Oh, M.S., Hong, S.J., Huh, Y., and Kim, K.S. (2009). Expression of transgenes in midbrain dopamine neurons using the tyrosine hy ...
STAR+METHODS KEY RESOURCES TABLE CONTACT FOR REAGENT AND RESOURCE SHARING Please direct all methodological and resource sharing ...
(pAAV5-EF1a-dio-hChR2(H123R)-EYFP-WPRE-pA, UNC Vector Core). The total titer of both viruses was approximately 10^12 particles ( ...
Quantification and Statistical Analysis Statistical values including the exact n, the definition of center, dispersion and preci ...
Supplemental Figures Figure S1. ChR2 Immunoreactivity followed the Irregular Outline of the TH-Positive Cell Bodies in the Monke ...
Figure S2. An Example Optrode, Related toFigure 3 Optrodes were constructed by attaching a bare optical fiber to a custom made e ...
Figure S3. Optical Stimulation Biased Choices in the Absence of Exogenous Reward, Related toFigure 6 The choice experiment illus ...
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