Chromogranins from Cell Biology to Physiology and Biomedicine
134 fCgA4–16 frog CgA4–16 fCgA47–66 frog CgA47–66 ISO Isoproterenol NO Nitric Oxide NOS Nitric Oxide Synthase PI3K Phosphatidyl ...
135 CgA cleavage, at the level of the multiple pairs of dibasic sites which enrich its sequence, gives rise several bioactive fr ...
136 human) vertebrates. In all species examined so far, they exhibit a very high percentage identity and share important common ...
137 By using the isolated working heart preparation of frog as bioassay, specific sequences included in the VS-1 peptide [frog a ...
138 Table 1 Cardiac effects and mechanism of action of CGA-derived peptides (ND = Not Detected) CgA- derived peptides Basal cond ...
139 cytoskeleton as an important determinant of the signal-transduction cascade which underlies the inhibitory influence exerted ...
140 3 Catestatin CST (human CgA352–372, bovine CgA344–364) is a 21 amino acid cationic and hydrophobic peptide product of CgA pr ...
141 counteraction against excessive SAN activation, e.g., prolonged stress, HF, hyper- tensive cardiomyopathy (Angelone et al. 2 ...
142 that all the CST effects are mediated by ETBR, but not by ETAR, reinforces the hypothesis that the peptide actions involve t ...
143 mammalian and non-mammalian vertebrates have provided evidence that CST, by functioning as an endogenous NOS activator, also ...
14 4 cardiac counter-regulators under intense excitatory stimuli (e.g. CA-induced myo- cardial stress). In particular, while in ...
145 have evolved as components of the homeostatic control of cardiac function in verte- brates during evolutionary transitions. ...
146 Fung MM, Salem RM, Mehtani P, Thomas B, Lu CF, Perez B, Rao F, Stridsberg M, Ziegler MG, Mahata SK, O’Connor DT (2010) Direc ...
147 Maget-Dana R, Metz-Boutigue MH, Helle KB (2002) The N-terminal domain of chromogranin A (CgA1–40) interacts with monolayers ...
148 352– 372): naturally occurring amino acid variant Gly364Ser causes profound changes in human autonomic activity and alters r ...
© Springer International Publishing AG 2017 149 T. Angelone et al. (eds.), Chromogranins: from Cell Biology to Physiology and Bi ...
150 BAE-1 Bovine Aortic Endothelial cells BDM Butanedione monoxime bFGF Basic fibroblast growth factor BNP Brain natriuretic pep ...
151 and resistance vessels (Brekke et al. 2002 ). Initially identified as a potent endogenous nicotinic–cholinergic antagonist, ...
152 effects of VSs were independent from endocardial endothelium (EE) and nitric oxide–cGMP mechanism (Corti et al. 2004 ), in ...
153 rCgA1–64S-S). These experiments revealed that the presence of the disulfide bridge is required for the cardiotropic action o ...
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