Science - USA (2022-04-22)
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RESEARCH ARTICLE SUMMARY ◥ CANCER GENOMICS Substitution mutational signatures in whole-genomeÐsequenced cancers in the UK popula ...
RESEARCH ARTICLE ◥ CANCER GENOMICS Substitution mutational signatures in whole-genomeÐsequenced cancers in the UK population And ...
Degasperiet al.,Science 376 , eabl9283 (2022) 22 April 2022 2 of 15 GEL commonICGC common Hartwig common GEL rareICGC rare Hartw ...
from the same organ in different cohorts were more similar to each other than to those in other tissue types, providing reassuri ...
substitution (TBS) signature. Exploring all triple-base possibilities, we obtain an 864- channel profile that systematically rep ...
SBS14), DBS29 (associated with SBS20), and DBS37 (associated with SBS26) could all be gen- erated mathematically from their asso ...
intheGELcohortandcouldnotbecurated, owing to a lack of access to sequencing data. Contrasting previously unreported signatures w ...
Degasperiet al.,Science 376 , eabl9283 (2022) 22 April 2022 7 of 15 SBS6 0.000.02 0.040.06 0.080.10 0.12 C>A C>G C>T T& ...
[29 to 65 substitutions per megabase (subs/ Mb)] and an even higher indel rate (67 to 99 indels/Mb). All three GEL cases also ha ...
In bladder cancers (three cases), there is a marked DBS pattern despite low mutational burden (0.15 to 8 subs/Mb). The cause for ...
6subs/Mb)acrossmanysamplesofthesetu- mor types. It is a common signature in kid- ney and bladder cancers (1461/1704) and is akin ...
From a biological perspective, it is essential to distinguish signatures that provide diagnos- tic insights or that are therapeu ...
detectable using WGS signatures but for which a genetic driver cannot be identified. It is noteworthy that a causal genetic even ...
representation of the process in any given tissue. For users seeking to learn what signatures may be present in a new set of sam ...
signatures were used in one single signature- fitting process. Each signature-fit strategy pro- duced a first estimate of the ex ...
genomes (450 from EGAS00001001178 and 80 from EGAD00001002740). The HMF cohort can be accessed via at http://www.hartwigmedicalf ...
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RESEARCH ARTICLE SUMMARY ◥ CORONAVIRUS Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B.1. ...
RESEARCH ARTICLE ◥ CORONAVIRUS Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B.1.1.529 To ...
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