Drug Metabolism in Drug Design and Development Basic Concepts and Practice

from vesicles, the drug uptake into membrane vesicles can reach a maximum level and then decrease (‘‘overshoot’’ phenomenon). Th ...

expressed on the apical cell membrane, thenPapp, A-to-B<Papp, B-to-A; if an uptake transporterisexpressed ontheapicalcell mem ...

The cytotoxicity assay is an indirect measurement of the accumulation of cytotoxic compounds in cells and is a frequently used s ...

low endogenous transporter background and short expression turnaround time (4–7 days). Additionally, the cells can perform the a ...

transporters are expressed in the transfected cell lines when using a transfected cell line to map transporter substrate. The ve ...

(Mdr1) or Mrp2 mutations have been identified in mice (Lankas et al., 1997; Kwei et al., 1999), rats (Buechler et al., 1996; Elf ...

GF120918 did not increase the exposure to orally administered etoposide, suggesting that Bcrp1 activity is not a major limiting ...

transporters, this is open for interpretation and discussion. Once the comments from industry and academia are received by the F ...

Arnadottir M, Eriksson LO, Thysell H, Karkas JD. Plasma concentration profiles of simvastatin 3-hydroxy-3-methyl-glutaryl-coenzy ...

Boulton DW, DeVane CL, Liston HL, Markowitz JS.In vitroP-glycoprotein affinity for atypical and conventional antipsychotics. Lif ...

Cohen A, Ullman B, Martin DW Jr. Characterization of a mutant mouse lymphoma cell with deficient transport of purine and pyrimid ...

clearance; US. Pat. Appl. Publ. 32 pp., Cont.-in-part of U.S. Ser. No. 815,300. USA,2002. Fotoohi AK, Lindqvist M, Peterson C, A ...

Hamman MA, Bruce MA, Haehner-Daniels BD, Hall SD. The effect of rifampin administration on the disposition of fexofenadine. Clin ...

Ieiri I, Suzuki H, Kimura M, Takane H, Nishizato Y, Irie S, Urae A, Kawabata K, Higuchi S, Otsubo K, Sugiyama Y. Influence of co ...

Kilic T., Alberta JA, Zdunek PR, Acar M, Iannarelli P, O’Reilly T, Buchdunger E., Black PM, Stiles CD. Intracranial inhibition o ...

for interspecies differences in mitochondrial toxicity of fialuridine. J Biol Chem 2006. LeisJ,StepanD,CurtinP,FordJ,PengB,Schub ...

cyclosporine in a phase I trial to modulate multidrug resistance. J Clin Oncol 1992;10:1635–1642. Mackey JR, Baldwin SA, Young J ...

Mouly SJ, Paine MF, Watkins PB. Contributions of CYP3A4, P-glycoprotein, and serum protein binding to the intestinal first-pass ...

resistance to chloroquine in human CEM T cells is mediated by multidrug resistance- associated protein 1 and provokes high level ...

Polli JW, Baughman TM, Humphreys JE, Jordan KH, Mote AL, Webster LO, Barnaby RJ, Vitulli G, Bertolotti L, Read KD, Serabjit-Sing ...