Devita, Hellman, and Rosenberg's Cancer

LWBK1006-24 LWW-Govindan-Review December 12, 2011 19:15

332 DeVita, Hellman, and Rosenberg’s CANCER: Principles and Practice of Oncology Review

Question 24.5. Which syndrome is characterized by the presence of breast cancer, soft

tissue sarcoma, leukemia, and prostate cancer?

A. Li-Fraumeni syndrome

B. Cowden syndrome

C. Peutz-Jeghers syndrome

D. Ataxia-telangiectasia

Question 24.6. Which frequently mutated gene is present in 17q21?

A. BRCA1

B. BRCA2

C. PTEN

D. P53

Question 24.7. Which of the following factors is NOT associated with a relative risk

higher than 4 for developing breast cancer?

A. Radiation exposure before age of 40

B. BRCA1 mutation

C. CHEK2 mutation

D. Lobular carcinoma in situ

Question 24.8. Based on the Women’s Health Initiative Study, the use of postmenopausal

combined estrogen and progestin therapy:

A. Increased the frequency of abnormal mammograms after 1 year

B. Doubled the risk of developing breast cancer after 4 years

C. Doubled the risk of developing breast cancer after 2 years

D. Did not alter the likelihood of having nodal involvement at diagnosis

Question 24.9. Which of the following is associated with the highest risk of breast cancer?

A. Postmenopausal obesity

B. Dense breasts on mammogram

C. Postmenopausal estrogen plus progestin therapy

D. Nulliparity

Question 24.10. Current evidence does NOT support the addition of screening breast

magnetic resonance imaging (MRI) for which of the following patients?

A. A 25-year-old woman with a deleterious mutation in BRCA2

B. A 66-year-old woman who underwent lumpectomy and radiation for

a high-grade ductal cancer in situ (DCIS) 2 years ago

C. A 32-year-old woman whose sister tested positive for a deleterious

mutation in BRCA1 (she has declined testing)

D. A 35-year-old woman who underwent mantle radiation for Hodgkin’s

disease at age 16 years