Cannabinoids

360 B. Szabo and E. Schlicker Izzo AA, Mascolo N, Borrelli F, Capasso F (1998) Excitatory transmission to the circular muscle of ...

Effects of Cannabinoids on Neurotransmission 361 Mackie K, Lai Y, Westenbroek R, Mitchell R (1995) Cannabinoids activate an inwa ...

362 B. Szabo and E. Schlicker Nemeth J, Helyes Z, Than M, Jakab B, Pinter E, Szolcsanyi J (2003) Concentration-dependent dual ef ...

Effects of Cannabinoids on Neurotransmission 363 Rodriguez JJ, Mackie K, Pickel VM (2001) Ultrastructural localization of the CB ...

364 B. Szabo and E. Schlicker Szabo B, Dörner L, Pfreundtner C, Nörenberg W, Starke K (1998) Inhibition of GABAergic inhibitory ...

Effects of Cannabinoids on Neurotransmission 365 Vaughan CW, Connor M, Bagley EE, Christie MJ (2000) Actions of cannabinoids on ...

HEP (2005) 168:367–383 ©cSpringer-Verlag 2005 Retrograde Signalling by Endocannabinoids C.W. Vaughan · M.J. Christie (
) Pain Ma ...

368 C.W. Vaughan and M.J. Christie mission via presynaptic CB 1 -mediated mechanisms. More recently, it has been established tha ...

Retrograde Signalling by Endocannabinoids 369 activity of anandamide and 2-AG is terminated by uptake and subsequent degra- dati ...

370 C.W. Vaughan and M.J. Christie Fig.1A–CDSIismediatedbyendogenouscannabinoids.AA5-sdepolarisingstepproducesatransientreduc- t ...

Retrograde Signalling by Endocannabinoids 371 and onto dopaminergic neurons within the ventral tegmental area (Melis et al. 2004 ...

372 C.W. Vaughan and M.J. Christie cannabinoid receptors, metabotropic glutamate receptors (mGluR) belong to the G protein-coupl ...

Retrograde Signalling by Endocannabinoids 373 tion. Low concentrations of mGluR and mAChR agonists, which alone produce little p ...

374 C.W. Vaughan and M.J. Christie group I mGluR agonists (Robbe et al. 2002; Chevaleyre and Castillo 2003). Evidence in favour ...

Retrograde Signalling by Endocannabinoids 375 hibition of GABAergic and glutamatergic synaptic transmission in the hippocam- pus ...

376 C.W. Vaughan and M.J. Christie processes of endocannabinoid production and retrograde signalling. Ultimately, the issue of w ...

Retrograde Signalling by Endocannabinoids 377 4.3 Inhibitors of Uptake and Metabolism External application of the AMT transport ...

378 C.W. Vaughan and M.J. Christie Fig. 3A, BTonic release of anandamide presynaptically facilitates glutamatergic synaptic tran ...

Retrograde Signalling by Endocannabinoids 379 Fig. 4.Model depicting how endogenously released cannabinoids act as retrograde me ...

380 C.W. Vaughan and M.J. Christie coordination. The possibility that drugs selective for one cannabinoid receptor type could ov ...