Cannabinoids

422 G.A. Cabral and A. Staab Schatz AR, Lee M, Condie RB, Pulaski JT, Kaminski NE (1997) Cannabinoid receptors CB1 and CB2: a ch ...

Effects on the Immune System 423 Titishov N, Mechoulam R, Zimmerman AM (1989) Stereospecific effects of (–)- and (+)-7- hydroxy- ...

HEP (2005) 168:425–443 ©cSpringer-Verlag 2005 Imaging of the Brain Cannabinoid System K.P. Lindsey^1 (
) · S.T. Glaser · S.J. Ga ...

426 K.P. Lindsey et al. of cannabinoid drugs on brain metabolism. In vivo neuroimaging, in contrast to autoradiography, utilizes ...

Imaging of the Brain Cannabinoid System 427 Both autoradiographical and in vivo studies of drugs of abuse such as cannabis may h ...

428 K.P. Lindsey et al. as the dopaminergic system, can be assessed. This strategy has been utilized to date only accidentally i ...

Imaging of the Brain Cannabinoid System 429 and neuronal cell membranes, and also for hexokinase. Since it cannot proceed furthe ...

430 K.P. Lindsey et al. to assess changes in synaptic dopamine (Laruelle 2000). SPECT can also be used to visualize relative per ...

Imaging of the Brain Cannabinoid System 431 between control subjects and drug abusers can be measured. Furthermore, high- resolu ...

432 K.P. Lindsey et al. 14 days before receptor autoradiography. Downregulation was largely progressive, yet highly variable bet ...

Imaging of the Brain Cannabinoid System 433 regions, consistent with the effects of∆^9 -THC on memory, sensory perception, and m ...

434 K.P. Lindsey et al. THC at doses ranging from 0.5 to 16 mg/kg 30 min prior to sacrifice had variably decreased rCBFin 16 bra ...

Imaging of the Brain Cannabinoid System 435 Fig. 1.Representative structures of the different cannabinoid receptor ligand classe ...

436 K.P. Lindsey et al. in Gatley and Volkow 1998) in that single acute administrations of∆^9 -THC did not reduce overall metabo ...

Imaging of the Brain Cannabinoid System 437 cingulate was associated with subject-reported sensations of depersonalization (Math ...

438 K.P. Lindsey et al. in which the cerebellum plays a key role (Varma et al. 1988). The lack of signifi- cant changes in blood ...

Imaging of the Brain Cannabinoid System 439 2000). Additionally, the subjects who began using marijuana earlier had smaller gray ...

440 K.P. Lindsey et al. References Adams IB, Compton DR, Martin BR (1998) Assessment of anandamide interaction with the cannabin ...

Imaging of the Brain Cannabinoid System 441 Dewey SL, Smith GS, Logan J, Brodie JD, Fowler JS, Wolf AP (1993b) Striatal binding ...

442 K.P. Lindsey et al. Mathew RJ, Wilson WH, Chiu NY, Turkington TG, Degrado TR, Coleman RE (1999) Regional cerebral blood flow ...