Cannabinoids

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654 J.A. Ramos et al.


Fernández-Ruiz JJ, Bonnin A, de Miguel R, Castro JG, Ramos JA (1998) Perinatal exposure


to marihuana or its main psychoactive constituent,∆^9 -tetrahydrocannabinol, affects


the development of brain dopaminergic neurons. Arq Med 12:67–77
Fernández-Ruiz JJ, Berrendero F, Hernandez ML, Romero J, Ramos JA (1999) Role of endo-
cannabinoids in brain development. Life Sci 65:725–736
Fernández-RuizJJ,BerrenderoF,HernandezML,RamosJA(2000)Theendogenouscannabi-
noid system and brain development. Trends Neurosci 23:14–20
Fride E, Mechoulam R (1996a) Developmental aspects of anandamide: ontogeny of response
and prenatal exposure. Psychoneuroendocrinology 21:157–172
Fride E, Mechoulam R (1996b) Ontogenic development of the response to anandamide and


∆^9 -tetrahydrocannabinol in mice. Brain Res Dev Brain Res 95:131–134


FrideE,GinzburgY,BreuerA,BisognoT,DiMarzoV,MechoulamR(2001)Criticalroleofthe
endogenous cannabinoid system in mouse pup suckling and growth. Eur J Pharmacol
419:207–214
Fried PA, Smith AM (2001) A literature review of the consequences of prenatal marihuana
exposure. An emerging theme of a deficiency in aspects of executive function. Neuro-
toxicol Teratol 23:1–11


García-Gil L, de Miguel R, Ramos JA, Fernández-Ruiz JJ (1996) Perinatal∆^9 -tetrahydro-


cannabinol exposure in rats modifies the responsiveness of midbrain dopaminergic
neurons in adulthood to a variety of challenges with dopaminergic drugs. Drug Alcohol
Depend 42:155–166

García-Gil L, Ramos JA, Rubino T, Parolaro D, Fernández-Ruiz JJ (1998) Perinatal∆^9 -tetra-


hydrocannabinol exposure did not alter dopamine transporter and tyrosine hydroxylase
mRNA levels in midbrain dopaminergic neurons of adult male and female rats. Neuro-
toxicol Teratol 20:549–553
García-Gil L, Romero J, Ramos JA, Fernández-Ruiz JJ (1999a) Cannabinoid receptor binding
and mRNA levels in several brain regions of adult male and female rats perinatally


exposed to∆^9 -tetrahydrocannabinol. Drug Alcohol Depend 55:127–136


García-Gil L, de Miguel R, Romero J, Perez A, Ramos JA, Fernández-Ruiz JJ (1999b) Peri-


natal∆^9 -tetrahydrocannabinol exposure augmented the magnitude of motor inhibition


caused by GABA-B but not GABA-A, receptor agonists in adult rats. Neurotoxicol Teratol
21:277–283
Glass M, Dragunow M, Faull RLM (1997) Cannabinoid receptors in the human brain:
a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and
adult human brain. Neuroscience 77:299–318
Goldschmidt L, Day NL, Richardson GA (2000) Effects of prenatal marihuana exposure on
child behavior problems at age 10. Neurobehav Toxicol 22:325–336
Gómez M, Hernández ML, Johansson B, de Miguel R, Ramos JA, Fernández-Ruiz J (2003)
Prenatal cannabinoid exposure and gene expression for neural adhesion molecule L1 in
the fetal rat brain. Brain Res Dev Brain Res 147:201–207
González B, de Miguel R, Martin S, Perez-Rosado A, Romero J, García-Lecumberri C,


Fernández-Ruiz J, Ramos JA, Ambrosio E (2003) Effects of perinatal exposure to∆^9 -


tetrahydrocannabinol on operant morphine-reinforced behavior. Pharmacol Biochem
Behav 75:577–584
Harbison RD, Mantilla-Plata B (1972) Prenatal toxicity, maternal distribution and placental
transfer of tetrahydrocannabinol. J Pharmacol Exp Ther 180:446–453
Herkenham M, Lynn AB, Johnson MR, Melvin LS, de Costa BR, Rice KC (1991) Character-
ization and localization of cannabinoid receptors in rat brain: a quantitative in vitro
autoradiographic study. J Neurosci 11:563–583


Hernández ML, García-Gil L, Berrendero F, Ramos JA, Fernández-Ruiz JJ (1997)∆^9 -tetra-


hydrocannabinol increases activity of tyrosine hydroxylase in cultured fetal mesen-
cephalic neurons. J Mol Neurosci 8:83–91
Hernández ML, Berrendero F, Suarez I, Garcia-Gil L, Cebeira M, Mackie K, Ramos JA,
Fernández-Ruiz JJ (2000) Cannabinoids CB1 receptors colocalize with tyrosine hydrox-

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