b2815 Tissue Engineering and Nanotheranostics “9.61x6.69”38 Tissue Engineering and Nanotheranostics
Uniaxial testing would be of equal importance in the case of fetal
patches, since they would give an idea about the patch response and
integrity during fetal growth. The placement of the patch at the right
position would also carry value if the patch demonstrates anisotropy.
An experimental analysis carried out by Velayudhan and
Martin^18 evaluate the dynamic creep properties of four commonly
used hernia meshes (Prolene®, Ultrapro®, Vypro® and Vypro® II),
primarily consisting of non-absorbable PP.^18 Dynamic creep tests
were executed on an EnduraTEC BioDMA, using a 250-N load
cell.^18 Mesh specimens were cut along machine (warp) and perpen-
dicular (weft) directions; and subjected to force controlled sinusoidal
oscillation for 100,000 cycles at a frequency of 1 Hz.^18 The chosen
mean load for each experiment was 16 N/cm, which was based on
physiological load values and force amplitude of 4 N was retained.^19
Secant modulus was determined from the slope of the hysteresis
loop. The dynamic creep behavior was probed in phosphate buffer
saline (PBS, pH = 7.3) at 37°C, which effectively simulated physio-
logical environments. The secant moduli increased gradually for all
Fig. 6. Bar graphs depicting the maximum load of the mesh materials.^14(^130) p<0.0001 p<0.0001 p<0.0001 p<0.047 p<0.0001 p<0.0001
120
110
100
90
80
70
60
max. Force/N 50
40
30
20
10
0
DYNAMESH®PARIETENE®PR
OLENE®
SURGIPR
O®
ULTRAPR
O®
VICR
YL®
abdom.
wall, trans
, [10]
abdom.
wall, trans
, [11]
abdom.
wall, long,
[11]
linea alba, trans
[12]
linea alba, long [12]
Strong Direction Weak Direction Human Data