Treatment of Inflammatory Bowel Disease with Biologics
51 Axial Arthritis Anklylosing spondylitis (AS) and sacroiliitis are associated with IBD, although they occur less frequently th ...
52 with underlying IBD [ 26 – 31 ]. Infliximab seems to be more effective than etaner- cept, and adalimumab may be more effectiv ...
53 evaluated at 2 and 6 weeks based on patient questionnaires and physician assessment. At week two, there was improvement in 46 ...
54 of infliximab versus placebo in 10 patients with PSC did not show biochemical, symptomatic, or histologic differences between ...
55 Conclusion Anti-TNFs provide a valuable tool for the treatment of multiple EIM of IBD, although the data supporting their use ...
56 Barreiro-de-Acosta M, Lorenzo A, Dominguez-Munoz JE. Efficacy of adalimumab for the treatment of extraintestinal manifestat ...
57 Suhler EB, Smith JR, Wertheim MS, Lauer AK, Kurz DE, Pickard TD, et al. A prospective trial of infliximab therapy for refrac ...
© Springer International Publishing AG 2018 59 A.S. Cheifetz, J.D. Feuerstein (eds.), Treatment of Inflammatory Bowel Disease wi ...
60 Crohn’s Disease Activity Index (CDAI) score suggesting a significant discordance between clinical symptoms and endoscopic fin ...
61 using the Rutgeerts score has not been validated as a measure of treatment response. Intra- observer reliability using the Ru ...
62 fecal calprotectin can be a useful, noninvasive screening tool for detecting of POR. In an analysis of a randomized controlle ...
63 revealed an accuracy of 93.7% in detecting POR confirmed by radiography and endoscopy and biopsy, 82% sensitive and 100% spec ...
64 There are several patient-related factors that have had discordant associations resulting in inconclusive interpretation. Pat ...
65 to reach significance (OR 1.58, 95% CI 0.97–2.57, p = 0.06) which the authors felt was likely due to study heterogeneity (Coc ...
66 stapled anastomosis (0%, 0%, and 3%, respectively) compared to sutured end to end (5%, 11%, and 24%, respectively, plog-rank ...
67 POR. A Cochrane analysis by Doherty et al. demonstrated a significant reduction in both clinical recurrence (RR 0.75, 95% CI ...
68 AZA (100–150 mg daily depending on body mass) for 12 months had significantly less endoscopic recurrence (Rutgeerts i2–i4) at ...
69 as increased risk if they had at least one (or more) prior resection within 10 years, or resection for a penetrating complica ...
70 activity in the IFX-treated group (80% AZA vs. 18% IFX). There were no signifi- cant differences in clinical recurrence after ...
71 significantly superior. Of the examined treatment modalities, only budesonide (RR 0.93, 95% CI 0.40–1.84) was not significant ...
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