Treatment of Inflammatory Bowel Disease with Biologics
114 pegol, a humanized injectable anti-TNF, is a pegylated Fab’ fragment and has dem- onstrated efficacy in inducing and maintai ...
115 significantly shorter in those who had detectable ATIs compared to those that did not [ 21 , 22 ]. The impact of anti-drug a ...
116 including internalization and phagocytosis with lysosomal degradation or endocy- tosis and catabolism by the reticuloendothe ...
117 patients assessing the association between drug levels of infliximab and adalim- umab and mucosal healing conducted by Ungar ...
118 Measuring Drug Concentrations and Anti-drug Antibodies Several assays have been developed to measure anti-TNF drug levels an ...
119 ELISA-based assays are not currently employed in most commercial tests for anti-TNF levels and antibodies. An alternative to ...
120 Employing Drug Level and Antibody Data in Clinical Care: Therapeutic Drug Monitoring With data demonstrating the association ...
121 such as overlapping irritable bowel syndrome, infection, bile salt diarrhea, bacterial overgrowth, or other causes. Once inf ...
122 Another retrospective study examined 199 CD and 42 UC patients, of which 140 were receiving infliximab and 107 were receivin ...
123 Several recent studies have attempted to assess the clinical efficacy of proactive TDM, all with infliximab. Cheifetz and co ...
124 as albumin, weight, disease activity and burden, etc., and therefore TDM will probably be more accurate on an individual rat ...
125 and anti-drug antibodies. Evidence is also mounting for the use of commercial assays to perform TDM when patients have recur ...
126 Sandborn WJ, van Assche G, Reinisch W, et al. Adalimumab induces and maintains clini- cal remission in patients with moder ...
127 Li J, Paulson SK, Chiu Y-L, Robinson A, Lomax KG, Pollac PF. Evaluation of potential cor- relations between serum adalimuma ...
128 Papamichael K, Van Stappen T, Jairath V, et al. Review article: pharmacological aspects of anti-TNF biosimilars in inflamm ...
© Springer International Publishing AG 2018 129 A.S. Cheifetz, J.D. Feuerstein (eds.), Treatment of Inflammatory Bowel Disease w ...
130 healing, TNF-α stimulates fibroblast proliferation and recruitment into the wound. These functions contribute to the role in ...
131 At the Mayo Clinic in Scottsdale, Arizona, 30-day postoperative complications were measured through historical cohorts betwe ...
132 classification, type of surgery, and number of intestinal anastomoses. However, patients without perioperative treatment wer ...
133 defunctionalizing proximal stoma to reduce postoperative complications. Considering penetrating disease as a predictor in th ...
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