Topology in Molecular Biology
4 Dynamics of DNA Supercoiling 49 and increasing the superhelix density (Riis reduced andPiis increased), which causes a decreas ...
50 A. Gabibov et al. Generally, the shape ofρ(σ) curves is similar for a number of tested plas- mids. However, quantitatively, t ...
4 Dynamics of DNA Supercoiling 51 However a full set of the constants regarding human topoisomerases is not available. In this c ...
52 A. Gabibov et al. This scheme reflects the most probable mechanism of top II action [27, 28]. Free enzyme associates with the ...
4 Dynamics of DNA Supercoiling 53 formation (k∼n=k 0 exp((2Bn+1)/RT)and∼kn=k 0 exp(−(2Bn+1)/RT)) (Fig. 4.4b). After formation of ...
54 A. Gabibov et al. 〈〉 Fig. 4.5.Kinetic analysis of the scDNA transformations catalysed by topoisomerase I. (a) Computer simula ...
4 Dynamics of DNA Supercoiling 55 〈σ〉 Fig. 4.6.Kinetic analysis of the scDNA transformations catalysed by topoisomerase II. (a) ...
56 A. Gabibov et al. Fig. 4.7.FLD and gel electrophoresis analysis of scDNA relaxation catalysed by human topoisomerase 1–3′.(a) ...
4 Dynamics of DNA Supercoiling 57 by FLD technique (data not shown). One can explain the latter observa- tion taking into accoun ...
58 A. Gabibov et al. form. Experiments with the native enzyme demonstrated that topoisomerase I more actively forms covalent com ...
4 Dynamics of DNA Supercoiling 59 (a) (b) Fig. 4.9.DNA-topoisomerase interface calculated using advanced Voronoi tessel- lation. ...
60 A. Gabibov et al. simply not relevant for the description of the kinetics. In contrast, the in- teraction of relaxed DNA and ...
4 Dynamics of DNA Supercoiling 61 relaxed. On the other hand, the mixture composition is crucial for the velocity of the process ...
62 A. Gabibov et al. Summarising these statements one can conclude that all aspects of topoisomerase I kinetics could be describ ...
4 Dynamics of DNA Supercoiling 63 4.2.4 Dynamics of Drug Targeting The FLD technique can prove very useful in studies of the int ...
64 A. Gabibov et al. of re-ligation of nicked DNA chain (see Scheme 4.1a) [36, 37]. As shown in Fig. 4.13, in the presence of th ...
4 Dynamics of DNA Supercoiling 65 Fig. 4.14.Inhibition of topoisomerase II activity measured by FLD technique. Experimental cond ...
66 A. Gabibov et al. of Scientific Schools (4182.2006.1). We are very thankful for the stimulating discussions with late Profess ...
4 Dynamics of DNA Supercoiling 67 J. Roca, J.C. Wang, Cell 71 , 833–840 (1992) A.V. Vologodskii, W. Zhang, V.V. Rybenkov et al. ...
5 From Tangle Fractions to DNA L.H. Kauffman and S. Lambropoulou Summary.This chapter draws a line from the elements of tangle f ...
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