Science - USA (2022-06-03)
In addition, across progenitor lineages, cells of different developmental stages were simul- taneously present in peripheral org ...
to lymphoid aggregates in the spleen (fig. S24B), in addition to their expected presence in the developing liver (Fig. 4C and fi ...
Suoet al., Science 376 , eabo0510 (2022) 3 June 2022 8of15 Fetal B 1 cell CD27 CD43 CD27 CD43 CCR10 CCR 10 high fetal B 1 IGL IG ...
surrounded by several neighboring DP cells from the same clone. It is therefore plausible that it requires less physical migrati ...
Suoet al., Science 376 , eabo0510 (2022) 3 June 2022 10 of 15 TRAV genesTRAJ genes clone of proliferating DP transition stage tr ...
Optimal 18-min permeabilization was selected for fetal spleen and liver, and a 24-min per- meabilization was used for fetal thym ...
kidney, and gut). The cell count in neighbor- hoods was modeled as a negative-binomial generalized linear model using a log-line ...
the KNN-classifier approach described in ( 15 ) was adapted and the similarity to prenatal cells labeled was calculated taking t ...
M. Lotfollahiet al., Mapping single-cell data to reference atlases by transfer learning.Nat. Biotechnol. 40 , 121– 130 (2022). ...
K. Polański et al., BBKNN: Fast batch alignment of single cell transcriptomes.Bioinformatics 36 ,964–965 (2020). pmid: 31400197 ...
RESEARCH ARTICLE ◥ NEURODEVELOPMENT Contrastive machine learning reveals the structure of neuroanatomical variation within autis ...
t 9 = 124.83,p < 0.001). Thus, the CVAE was able to factor out a common source of“nui- sance”variationinmultisitedata( 10 ). ...
ensuring that a machine-learning model will generalize to an arbitrary new dataset (or in- deed, ensuring that any scientific fi ...
optimal number of clusters using the Bayesian information criterion (BIC) (Fig. 1D). Because CVAEs and VAEs are probabilistic, w ...
A. Aglinskas, SCCN Lab, sccnlab/pub-CVAE-MRI-ASD: Code release for reproducibility. Zenodo (2022); https://doi.org/10. 5281/zen ...
BIOCHEMISTRY Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy Stanley C. Xie^1 ...
E1 that activates UBLs—including the Atg8s ( 11 ). We identified several pyrazolopyrimidine sulfamates with a 7-position substit ...
0.4 nM) both validatesPf YRS as the target and points to an extremely potent inhibitory interaction. ML901 inhibits protein tran ...
were generated through in vitro transcription (fig. S10). When ML901 was incubated with Pf YRS in the presence of all other subs ...
precipitated the tRNA and protein. The super- natant was subjected to LCMS analysis and we detected a peak at m/z 576.1331 Da (F ...
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