0071483446.pdf

(^220) CHAPTER 13 Antimicrobials—Fighting Infection
Second Generation: Increased activity against gram (−)
microorganisms (continued)
Pregnancy Category: B
Route Dose Time
Cefurozine (Ceftin, Zinacef)
Protein-Binding: 50%
Half-Life: 1.5–2 hours
PO 250–500 mg Every 12 hours
IM/IV 0.75–1.5 g Every 8 hours
Loracarbef (Lorabid)
Protein-Binding: Unknown
Half-Life: 1 hour
PO 200–400 mg Every 12 hours
Third Generation: More active against gram (−);
ceftazidime and cefoperazone are also effective against
Pseudomonas aeruginosa(gram−) and b-lactamase-
producing microbial strains; less effective against
gram (+) cocci
Pregnancy Category: B
Route Dose Time
Cefixime (Suprax)
Protein-Binding: 65%
Half-Life: 2.5–4 hours
PO 200 mg Every 12 hours
Cefoperazone (Cefobid)
Protein-Binding: 70%–80%
Half-Life: 2.5 hours
IV 1–2 g Every 12 hours
Cefotaxime (claforan)
Protein-Binding: 30%–40%
Half-Life: 1–1.5–3 hours
IV 1–2 g Every 12 hours