Science - USA (2022-05-27)
factors, hormones, cytokines, inflammation, and stresses. It controls the expression of many downstream genes related to cell di ...
adjustedP < 0.05) ( 12 ). Finally, the relative expression levels of predicted key TFs in each of the four groups were confir ...
(tables S5 and S9). A template was constructed for each subtype by combining the top signa- ture genes. To assign the CRPC patie ...
and 100 patients sequenced at Weill Cornell Medicine (WCM) (Fig. 4B). The majority of the patients (206 of 266 SU2C, 82 of 100 W ...
and 22Rv1 (Fig. 6C and fig. S19C;P < 0.0001, two-tailed unpairedt test). AP-1 and YAP/TAZ are important for subtype-specific ...
Tanget al., Science 376 , eabe1505 (2022) 27 May 2022 9of13 WANG_YAP_TAZ_TARGETSNES = -1.79 FDR = 0.001 Enrichment score (ES) D ...
well as TEAD, which cooperates with FOSL1 in our proposed model, similar to observations in other cancers ( 35 ). Using ChIP-seq ...
Tanget al., Science 376 , eabe1505 (2022) 27 May 2022 11 of 13 G F FOSL1 OETAZ^ OE TAZ/FO SL1 OEYAP OE YAP/FOSL1 OE -20% 0% 20% ...
of the CRPC-SCL group was validated by knock- down and exogenous overexpression assays followed by ATAC-seq, RNA-seq, and qPCR. ...
Janssen, AbbVie/Stemcentrx, Eli Lilly, Astellas, Millennium, and Bristol Myers Squibb. F.T. is an employee at AbbVie, L.P. is an ...
RESEARCH ARTICLE ◥ GLACIAL CYCLES Persistent influence of precession on northern ice sheet variability since the early Pleistoce ...
constructed by tuning to a target derived from a simple ice sheet model driven by 21 June insolation at 65°N (a signal dominated ...
with the U1385 age model (which extends back to 1.43 Ma; Fig. 3) but no peaks in this range pass the various significance tests ...
wasting coincided with the transition to in- terglacial conditions. Before 1 Ma, however, TIR events tended to end earlier with ...
offset could produce a TIR event that ended ~10 to 20 kyr before the midpoint of de- glaciation (Fig. 6D, events iv and v), ap- ...
Barkeret al., Science 376 , 961–967 (2022) 27 May 2022 6of7 Fig. 6. Changing orbits control the relative timing of terminal ice ...
effects of obliquity are weaker and those of precession stronger (Fig. 1). In turn, this could reflect the proposed net increase ...
DEVELOPMENT FTO mediates LINE1 m 6 A demethylation and chromatin regulation in mESCs and mouse development Jiangbo Wei1,2†,Xianb ...
lower 2C gene activation but greater down- regulation of ESC-high genes (fig. S5, A to E). Fto KO also caused several phenotypic ...
YTHDC1 binding, which could recruit nuclear decay machinery ( 22 ) and histone modifiers that add repressive histone marks ( 23 ...
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