Science - USA (2022-05-27)
ANTIBIOTIC DISCOVERY Bioinformatic prospecting and synthesis of a bifunctional lipopeptide antibiotic that evades resistance Zon ...
synthesis of macolacin, a colistin analog that is effective against pathogens that express the mcr-1resistance gene ( 6 ). In th ...
thesestrains.Wehavecalledtheactivestruc- ture cilagicin (Fig. 1E). Cilagicin was active against all Gram- positive pathogens tha ...
metabolite(s) that interacts with cilagicin, we screened a series of lipid II intermediates for their ability to suppress cilagi ...
P. mucilaginosus. The genusPaenibacillusis Gram variable.P. mucilaginosus’sreported negative Gram staining suggests that it con- ...
study of syn-BNPs that are inspired by un- explored BGC families should prove to be a productive strategy for identifying distin ...
IMMUNOLOGY The CD8a–PILRainteraction maintains CD8 T cell quiescence Linghua Zheng^1 ,XueHan^1 ,ShengYao^1 ,YuwenZhu^1 ,John ...
PILRais a transmembrane protein broadly expressed on myeloid cells, including macro- phages, dendritic cells, and neutrophils ( ...
decreased 2 days after 9B12 treatment (fig. S18D). In a complementary approach, treat- ment with 9B12 reduced the absolute numbe ...
This is reminiscent of B7’s interactions with both CD28 (promoting T cell activation) and CTLA-4 (suppressing T cell activation) ...
provide greater understanding of how naïve and memory T cell repertoires are main- tained and persist in normal and patholog- ic ...
Molecular Discovery, and Flow Cytometry Core Facility for their technical support.Funding:This study is partially funded by the ...
BIOMEDICINE A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy Yeon Sik Choi1,2 ...
(Si NM)], a pair of stretchable interconnects (Mo), and stimulation electrodes that integrate a steroid-eluting patch at the myo ...
Choiet al., Science 376 , 1006–1012 (2022) 27 May 2022 3of7 0200400 10 20 30 40 0 100 200 300 400 100 150 200 250 50 100 150 90 ...
of vibrotactile input ( 20 ). The respiratory mod- ule mounts at the suprasternal notch to capture physical activity, body tempe ...
respiratory activity (fig. S16). Figure 2, I to K, shows that the skin-interfaced modules and data analytics approaches accurate ...
protocol secure (HTTPS) transport layer sec- urity (TLS 1.2) and with algorithms for en- cryption and decryption (fig. S18). In- ...
and AliveCor.Data and materials availability:All data are available in the main text or the supplementary materials. License inf ...
ADAPTATION Genetic variance in fitness indicates rapid contemporary adaptive evolution in wild animals Timothée Bonnet^1 *, Mich ...
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