Science - USA (2022-05-27)
Tanget al., Science 376 , eabe1505 (2022) 27 May 2022 11 of 13 G F FOSL1 OETAZ^ OE TAZ/FO SL1 OEYAP OE YAP/FOSL1 OE -20% 0% 20% ...
of the CRPC-SCL group was validated by knock- down and exogenous overexpression assays followed by ATAC-seq, RNA-seq, and qPCR. ...
Janssen, AbbVie/Stemcentrx, Eli Lilly, Astellas, Millennium, and Bristol Myers Squibb. F.T. is an employee at AbbVie, L.P. is an ...
RESEARCH ARTICLE ◥ GLACIAL CYCLES Persistent influence of precession on northern ice sheet variability since the early Pleistoce ...
constructed by tuning to a target derived from a simple ice sheet model driven by 21 June insolation at 65°N (a signal dominated ...
with the U1385 age model (which extends back to 1.43 Ma; Fig. 3) but no peaks in this range pass the various significance tests ...
wasting coincided with the transition to in- terglacial conditions. Before 1 Ma, however, TIR events tended to end earlier with ...
offset could produce a TIR event that ended ~10 to 20 kyr before the midpoint of de- glaciation (Fig. 6D, events iv and v), ap- ...
Barkeret al., Science 376 , 961–967 (2022) 27 May 2022 6of7 Fig. 6. Changing orbits control the relative timing of terminal ice ...
effects of obliquity are weaker and those of precession stronger (Fig. 1). In turn, this could reflect the proposed net increase ...
DEVELOPMENT FTO mediates LINE1 m 6 A demethylation and chromatin regulation in mESCs and mouse development Jiangbo Wei1,2†,Xianb ...
lower 2C gene activation but greater down- regulation of ESC-high genes (fig. S5, A to E). Fto KO also caused several phenotypic ...
YTHDC1 binding, which could recruit nuclear decay machinery ( 22 ) and histone modifiers that add repressive histone marks ( 23 ...
responsive (fig. S13, F and G). We further ex- plored thecis -regulatory role of intragenic LINE1 RNAs suppressed byFtoKO and ob ...
RNA were also reversed in the rescued em- bryos (fig. S18, Q and R). Discussion In this work, we have shown functionally rel- ev ...
Association for the Advancement of Science. No claim to original US government works. https://www.science.org/about/science-lice ...
FERROELECTRICS Ferroelectricity in untwisted heterobilayers of transition metal dichalcogenides Lukas Rogée^1 †, Lvjin Wang^2 †, ...
on their piezo- and ferroelectric properties. In our case, the epitaxial heterobilayers do not show any moiré patterns (see text ...
The average of the vertical piezoelectric defor- mationDz of multiple 2H-like and 3R-like triangles was obtained by rigorous sta ...
a smaller square within that area (+8 V tip bias). These shapes are outlined in the phase and amplitude maps performed after pol ...
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