Nature - 2019.08.29

Letter reSeArCH over 24  h. Protein precipitates from BPSCSK-conditioned or nisin- A-spiked media, but not BPcontrol-conditioned ...

reSeArCH Letter 22 patients with a range of E. faecium densities and found lantibiotic gene abundance inversely correlated with ...

Letter reSeArCH and low E. faecium abundance, which suggests that diversity com- pensates for low lantibiotic-gene abundance by ...

reSeArCH Letter Methods Bacterial strains. Vancomycin-resistant E. faecium purchased from ATCC (stock number 700221) was used fo ...

Letter reSeArCH chromatography system at 4 °C. The lysate supernatant was loaded onto a HiTrap HP nickel affinity column. The co ...

reSeArCH Letter Statistics. Statistical analyses were performed using R (v.3.3.1) and GraphPad Prism (v.7.0a) software packages. ...

Letter reSeArCH Extended Data Fig. 1 | BPSCSK directly inhibits VRE through a contact- independent mechanism. a–d, VRE was co-cu ...

reSeArCH Letter Extended Data Fig. 2 | See next page for caption. ...

Letter reSeArCH Extended Data Fig. 2 | BPSCSK, but not BPcontrol, reduces VRE colonization in vivo. a, b, Faecal samples collect ...

reSeArCH Letter Extended Data Fig. 3 | BPSCSK colonizes the large intestine. Antibiotic- treated mice (n = 5 mice from one indep ...

Letter reSeArCH Extended Data Fig. 4 | CBBPSCSK mediates VRE colonization resistance by producing an inhibitor. a, Antibiotic-tr ...

reSeArCH Letter Extended Data Fig. 5 | See next page for caption. ...

Letter reSeArCH Extended Data Fig. 5 | BPSCSK encodes a lantibiotic. a, VRE was inoculated in media conditioned with BPSCSK or B ...

reSeArCH Letter Extended Data Fig. 6 | Heterologous expression of BPSCSK LanA 1 –LanA 4 lantibiotic. a, Genes involved in biosyn ...

Letter reSeArCH Extended Data Fig. 7 | Oral administrations of BPSCSK protein precipitate reduce VRE colonization in vivo. Antib ...

reSeArCH Letter Extended Data Fig. 8 | The BPSCSK lantibiotic has a narrower spectrum of activity against Gram-positive commensa ...

Letter reSeArCH Extended Data Fig. 9 | Identification of lantibiotic sequences from metagenomic sequencing of healthy human faec ...

reSeArCH Letter Extended Data Fig. 10 | Lantibiotic sequences identified from metagenomic sequencing of hospitalized patient fae ...

1 nature research | reporting summary October 2018 Corresponding author(s): Eric Pamer Last updated by author(s):Jul 16, 2019 Re ...

2 nature research | reporting summary October 2018 Field-specific reporting Please select the one below that is the best fit for ...