Science - USA (2020-01-03)
MULTIPLEX GENOMICS Massively multiplex chemical transcriptomics at single-cell resolution Sanjay R. Srivatsan1,2, José L. McFali ...
that had undergone a specific perturbation, followed by single-cell transcriptional profil- ing as a high-content phenotypic ass ...
microtubule destabilizer, rigosertib ( 27 ); the SETD8 inhibitor UNC0397; or untreated pro- liferating cells (fig. S7H). We next ...
A549), whereas other drugs induced much greater cellular heterogeneity (Fig. 4B and fig. S22). Such heterogeneity could be expla ...
farther along an aligned HDAC trajectory at 72 hours (fig. S26). This suggests that the dose of many HDAC inhibitors governs the ...
cytoplasmic citrate homeostasis (GLS, IDH1, and ACO1), citrate cellular import (SLC13A3), and mitochondrial citrate production a ...
MALARIA A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites Jakob Birnbaum^1 *†, Sarah Sc ...
10 colocalizing proteins, eight also colocalized in the resistance-relevant ring stage, whereas the other two (KIC8 and KIC9) we ...
best studied form of endocytosis is mediated by clathrin, which depends on the AP-2 adaptor complex ( 27 , 28 ). AlthoughP. falc ...
result from the method rather than being biologically meaningful (Fig. 2, B and C). This was supported by DiQ-BioID using the bi ...
effect in trophozoites agrees with the previous finding that inactivation of Kelch13 specifi- cally affected the ring stage only ...
reduces its overall activity. This idea is also suggested by our finding that reduced activ- ity of Kelch13 causes resistance (F ...
Birnbaumet al.,Science 367 ,51–59 (2020) 3 January 2020 7of9 Fig. 5. Reduced Kelch13 activity leads to ART resistance.(A) Heatma ...
wtKelch13 and endogenous Kelch13C580Y)ren- dered these resistant parasites fully sensitive to dihydroartemisinin (DHA) again (Fi ...
N. Abu Bakar, N. Klonis, E. Hanssen, C. Chan, L. Tilley, J. Cell Sci. 123 , 441–450 (2010). L. H. Bannister, J. M. Hopkins, G. ...
REPORT ◥ TOPOLOGICAL OPTICS A single photonic cavity with two independent physical synthetic dimensions Avik Dutt^1 , Qian Lin^2 ...
The tight-binding Hamiltonian describ- ing our system is H¼ X m;s ½wma†m;sam;sþ X m′ Jmm′ðtÞa†m;sam′;s X m Ka†m;↑am;↓eimf^0 ...
by choosing appropriateDL=L 0 .Becausea purely one-dimensional (1D) lattice does not permit magnetic field effects, our system c ...
above, one could not distinguish between the photon numbers atmL+mandmL−m modes, because they produce beat notes at thesameradio ...
from a single minimum atk=0(Fig.4,Aand E) to two minima (Fig. 4, B to H) at ( 19 ) kg;min¼Tarcsin ffiffiffiffiffiffiffiffiffiffi ...
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