Science 14Feb2020

STRUCTURAL BIOLOGY Structural basis for strand-transfer inhibitor binding to HIV intasomes Dario Oliveira Passos^1 , Min Li^2 , ...

Mg2+cofactors within the active site of IN. A halogenated benzyl moiety appended to the core by a short linker then displaces an ...

substrate envelope ( 29 ). The rationale is that if inhibitory compounds bind entirely within a conserved consensus volume occup ...

backbone of Asn^117 and Tyr^143 and projecting toward the bulk solvent. These bound water molecules can be exploited for the dev ...

BIODIVERSITY LOSS Tropical snake diversity collapses after widespread amphibian loss Elise F. Zipkin^1 *, Graziella V. DiRenzo1, ...

methods). We focused on estimating proba- bilities that species diversity and occurrence metrics changed from pre- to post-epizo ...

snake community, even with uncertainty in the exact number of species that declined. Al- though there are no direct effects of t ...

new products SCIENCE sciencemag.org/custom-publishing 14 FEBRUARY 2020 • VOL 367 ISSUE 6479 817 Produced by the Science/AAAS Cus ...

online @sciencecareers.org THE UNIVERSITY OF CHICAGO AcademicGastroenterologist–GeneralGI TheUniversityofChicago’sDepartmentofMe ...

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My best is good enough I waited until my Ph.D. committee had left the room to break down. I sank into a chair, head in hands, as ...