Nature - USA (2019-07-18)
1 nature research | reporting summary October 2018 Corresponding author(s): Carsen Stringer, Marius Pachitariu, Kenneth Harris L ...
2 nature research | reporting summary October 2018 Field-specific reporting Please select the one below that is the best fit for ...
Article https://doi.org/10.1038/s41586-019-1344-7 Structure and autoregulation of a P4-ATPase lipid flippase Milena timcenko1,5, ...
Article reSeArcH Overall structure and conformation The structures of Drs2p–Cdc50p in the E2Pinhib, E2Pinter and E2Pactive confo ...
reSeArcH Article However, truncation at residue 1302 maintains autoinhibition^26 and preserves the interactions with the A domai ...
Article reSeArcH this cleft (which is empty in our structures) marks the entry point of a lipid-transport pathway. The cleft par ...
reSeArcH Article opening of a putative substrate-binding site through the movement of TM2 away from TM6. We anticipate that subs ...
Article reSeArcH Methods Data reporting. No statistical methods were used to predetermine sample size. The experiments were not ...
reSeArcH Article MotionCor2^48 (implemented in RELION). Per-particle CTF refinement, with esti- mation of the beam tilt and Baye ...
Article reSeArcH Extended Data Fig. 1 | Activity of samples used for structural studies. a, P ost–Albers cycle for the Na+, K+-A ...
reSeArcH Article Extended Data Fig. 2 | Purification and negative-stain electron microscopy of samples for structural studies. a ...
Article reSeArcH Extended Data Fig. 3 | See next page for caption. ...
reSeArcH Article Extended Data Fig. 3 | Fold of Cdc50p. a, Cdc50p from E2Pinhib, shown in rainbow colours. Cα carbons of glycosy ...
Article reSeArcH Extended Data Fig. 4 | Characterization of PI4P-binding mutants. a, C oomassie-blue-stained SDS–PAGE of strepta ...
reSeArcH Article Extended Data Fig. 5 | Proposed lipid-translocation pathway and comparison between the three Drs2p–Cdc50p struc ...
Article reSeArcH Extended Data Fig. 6 | Processing pipeline for cryo-EM data of Drs2p– Cdc50p E2Pinhib. a, Representative motion ...
reSeArcH Article Extended Data Fig. 7 | See next page for caption. ...
Article reSeArcH Extended Data Fig. 7 | Processing pipeline for cryo-EM data of Drs2p–Cdc50p E2Pinter. a, Representative motion- ...
reSeArcH Article Extended Data Fig. 8 | Processing pipeline for cryo-EM data of Drs2p–Cdc50p E2Pactive. a, Representative motion ...
Article reSeArcH Extended Data Fig. 9 | Model validation and representative densities. a, Cr oss-validation FSC curves for map-t ...
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