Nature - USA (2020-08-20)

1 nature research | reporting summary October 2018 Corresponding author(s): James E. Crowe Last updated by author(s):8/01/2020 R ...

2 nature research | reporting summary October 2018 MT763532. Materials used in this study will be made available but may require ...

3 nature research | reporting summary October 2018 antibody for hACE2 binding assays. For FRNT assay, previously described human ...

4 nature research | reporting summary October 2018 Human research participants Policy information about studies involving human ...

450 | Nature | Vol 584 | 20 August 2020 Article Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike Lih ...

Nature | Vol 584 | 20 August 2020 | 451 among the highest. The clinical characteristics of these five patients are summarized in ...

452 | Nature | Vol 584 | 20 August 2020 Article we plotted in Extended Data Fig. 2b the best-fit neutralization curves for 130 s ...

Nature | Vol 584 | 20 August 2020 | 453 antibodies were slightly less potent, with IC 50 values ranging from 0.013 to 0.767 μg m ...

454 | Nature | Vol 584 | 20 August 2020 Article Fig. 5). We used ELISA to evaluate 16 non-RBD mAbs for competition in binding to ...

Nature | Vol 584 | 20 August 2020 | 455 Cryo-electron microscopy We produced cryo-electron microscopy (cryo-EM) reconstructions ...

456 | Nature | Vol 584 | 20 August 2020 Article memory B cells, while most groups have used the RBD^7 ,^9 –^11 ,^16 –^19 ,^21. T ...

Methods No statistical methods were used to predetermine sample size. The experiments were not randomized and the investigators ...

Article MOI of 3 for 1 h before the cells were washed three times with 1× DPBS. DMEM supplemented with 2% fetal bovine serum, 10 ...

with three 2-4 Fabs bound, one to each RBD. A reconstruction of these particles using non-uniform refinement with imposed C3 sym ...

Article Goddard, T. D. et al. UCSF ChimeraX: meeting modern challenges in visualization and analysis. Protein Sci. 27 , 14–25 ( ...

Extended Data Fig. 1 | SARS-CoV-2 S trimer-specif ic antibody isolation strategy. a, Schema for isolating of S trimer-specific m ...

Article Extended Data Fig. 2 | Summary of mAb screening of transfection supernatants. a, Numbers of binding and neutralizing ant ...

Extended Data Fig. 3 | See next page for caption. ...

Article Extended Data Fig. 3 | Genetic features of SARS-CoV-2-specif ic antibody repertoire. a, 108 of the 123 antigen-specific ...

Extended Data Fig. 4 | Correlation of neutralizing antibody titres of the top 19 mAbs in the live SARS-CoV-2 assay versus the ps ...