Nature - USA (2020-10-15)

1 nature research | reporting summary April 2020 Corresponding author(s): Eric Klann, Prerana Shrestha Last updated by author(s) ...

2 nature research | reporting summary April 2020 Field-specific reporting Please select the one below that is the best fit for y ...

3 nature research | reporting summary April 2020 Rabbit anti- p-S6K1 Thr389 1:500 (Cell Signaling #9205) The p-S6K1 (T389) antib ...

4 nature research | reporting summary April 2020 Animals and other organisms Policy information about studies involving animals; ...

412 | Nature | Vol 586 | 15 October 2020 Article eIF2α controls memory consolidation via excitatory and somatostatin neurons Vij ...

Nature | Vol 586 | 15 October 2020 | 413 β-actin promoter (Enh-Pro)^19. The wild-type Eif2a transgene is flanked by LoxP sites ( ...

414 | Nature | Vol 586 | 15 October 2020 Article 1 h after contextual and cued fear conditioning (Extended Data Fig. 2c, d). How ...

Nature | Vol 586 | 15 October 2020 | 415 Data Figs. 7e (Eif2a cKISst), 8f (Eif2a cKIPvalb)). The puromycin incor- poration assay ...

416 | Nature | Vol 586 | 15 October 2020 Article cells. Via proximal disinhibition, they facilitate synaptic transmission and pl ...

Methods Animals and environment Neuronal subtype-specific eIF2α conditional knock-in (cKI) mice were generated by breeding Eif2a ...

Article delivered every 30 s in the stratum lacunosum-moleculare (SLM) region in CA1. After 30 min of stable baseline in the pre ...

Peptide and protein identification MS spectra were evaluated by Cell Signaling Technology using SEQUEST and the GFY-Core platfor ...

Article Extended Data Fig. 1 | Learning-induced reduction of p-eIF2α levels in excitatory and in the SST-expressing sub-populati ...

Extended Data Fig. 2 | Eif2a cKICamk2a mice show enhanced protein synthesis and consolidation of contextual and auditory fear me ...

Article Extended Data Fig. 3 | See next page for caption. ...

Extended Data Fig. 3 | CA1- or amygdala-specif ic reduction of p-eIF2α facilitates consolidation of contextual fear memory. a, R ...

Article Extended Data Fig. 4 | RiboTag. a, Schematic representation of the AAV-EF1α-DIO-Rpl22-3HA-IRES-YFP-WPRE-hGH polyA (AAV-D ...

Extended Data Fig. 5 | Analysis of excitatory neurons-specif ic translational landscape and proteomics from hippocampi of Eif2a ...

Article Extended Data Fig. 6 | See next page for caption. ...

Extended Data Fig. 6 | Consolidation of contextual and auditory fear memory and L-LTP induction is facilitated in Eif2a cKIGad2 ...