Nature - USA (2020-10-15)

Article was dissolved in saline and freshly prepared before every experiment. Saline and CNO imaging sessions were started 30 mi ...

was thawed the day of use and diluted 100-fold in 20% (v/v) acetonitrile containing 3% (v/v) sulfuric acid. BZC and NaCO 3 solut ...

Article entries, and percentage of time spent in the open arms were calculated as previously described^25. Olfaction test (sniff ...

Pnevmatikakis, E. A. & Giovannucci, A. NoRMCorre: an online algorithm for piecewise rigid motion correction of calcium imag ...

Article Extended Data Fig. 1 | See next page for caption. ...

Extended Data Fig. 1 | DREADD-based mouse models to study microglia responses to neuronal activation and inhibition reveals dist ...

Article Extended Data Fig. 2 | See next page for caption. ...

Extended Data Fig. 2 | Microglia def icient mice show normal baseline behaviours but exaggerated responses to neurostimulants. a ...

Article Extended Data Fig. 3 | See next page for caption. ...

Extended Data Fig. 3 | Generation and characterization of Il34-deficient and Csf 1-deficient mice. a, Violin plots show the expr ...

Article Extended Data Fig. 4 | See next page for caption. ...

Extended Data Fig. 4 | Generation of mice with striatum-specif ic microglia depletion. a, b, (left), The striatum-specific micro ...

Article Extended Data Fig. 5 | See next page for caption. ...

Extended Data Fig. 5 | Striatum-specif ic microglia reduction has no overall effects on striatal cellular composition, D1/D2 neu ...

Article Extended Data Fig. 6 | See next page for caption. ...

Extended Data Fig. 6 | Microglia regulate striatal neuron synchrony and responses to D1 agonist treatment in an ADO/A 1 R depend ...

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Extended Data Fig. 7 | Microglial expression of Entpd1/CD39 and Nt5e/CD73 in vitro and in vivo. a, Dot plots show normalized, ri ...

Article Extended Data Fig. 8 | See next page for caption. ...

Extended Data Fig. 8 | Microglia suppress neuronal activation via an ATP/AMP/ADO/A1R- dependent feedback mechanism. a, Scheme fo ...