Nature - USA (2020-09-24)

Nature | Vol 585 | 24 September 2020 | 531 non-destructive to their biological substrates); and low (or non-) reactivity towards ...

532 | Nature | Vol 585 | 24 September 2020 Article weaker catalysts Cat1 (Ru(bpy) 3 ; Eox = +0.77 V) and Cat2 (Ru(bpm) 3 , Eox = ...

Nature | Vol 585 | 24 September 2020 | 533 groups for potential initiation. First, remarkably, halo-pySOOF reagents pySOO–CF 2 – ...

534 | Nature | Vol 585 | 24 September 2020 Article On-protein heterolytic reactivity. Halides (1 s, 1t,1u, 2b, 2ad, 1v, 1w) are ...

Nature | Vol 585 | 24 September 2020 | 535 right and Supplementary Tables 25–34): mono-/di-substituted polar- ized acceptors, as ...

536 | Nature | Vol 585 | 24 September 2020 Article suggest a model (Extended Data Fig. 11d) in which KDM4A multimers sample pre- ...

Nature | Vol 585 | 24 September 2020 | 537 O’Hagan, D. Understanding organofluorine chemistry. An introduction to the C–F bond. ...

Article Methods General experiment protocol for BACED and pySOOF reagents For all protein-modification reactions, all aqueous bu ...

Extended Data Fig. 1 | Overview of radical side-chain installation and relevant previous literature. a, Retrosynthetic analysis ...

Article Extended Data Fig. 2 | Complementary strategies for mild protein-compatible photoredox reactions. a, Oxidative-half pote ...

Extended Data Fig. 3 | See next page for caption. ...

Article Extended Data Fig. 3 | Investigation and optimization of BACED chemistry. a, A 100% stacked bar chart (n = 1, with singl ...

Extended Data Fig. 4 | See next page for caption. ...

Article Extended Data Fig. 4 | Mechanistic investigation of the role of catechol in BACED reactions. a, Reaction scheme screenin ...

Extended Data Fig. 5 | See next page for caption. ...

Article Extended Data Fig. 5 | Initial experiments without iron using various hydride sources, and optimization study with sodiu ...

Extended Data Fig. 6 | See next page for caption. ...

Article Extended Data Fig. 6 | Optimization study of Fe(ii)-mediated protein modification reaction with pySOOF. a, In the photoc ...

Extended Data Fig. 7 | See next page for caption. ...

Article Extended Data Fig. 7 | Investigations on pySOOF reagent reactivity and on- protein mechanism. a, Effect of substituents ...