BNF for Children (BNFC) 2018-2019

Eliglustat(continued) ▶Eliglustatis predicted to increase the exposure totricyclic antidepressants(nortriptyline). Adjust dose.o ...

▶Enzalutamideis predicted to decrease the exposure to buspirone. Use with caution and adjust dose.rStudy ▶Enzalutamidemoderately ...

Enzalutamide(continued) ▶Enzalutamideis predicted to decrease the exposure to panobinostat. Avoid.oTheoretical ▶Enzalutamideis p ...

▶Crizotinibis predicted to increase the risk of ergotism when given withergometrine.rTheoretical ▶Ergometrineis predicted to inc ...

Erlotinib(continued) ▶Cobicistatis predicted to slightly increase the exposure to erlotinib. Use with caution and adjust dose.oS ...

▶Etravirineis predicted to decrease the exposure tobosutinib. Avoid.rTheoretical ▶Etravirineincreases the anticoagulant effect o ...

Fampridine ▶H 2 receptor antagonists(cimetidine)increase the concentration offampridine. Avoid.rTheoretical Febuxostat ▶Febuxost ...

▶Fibrates(bezafibrate, ciprofibrate)increase the risk of rhabdomyolysis when given withstatins(simvastatin). Adjust simvastatind ...

Fosaprepitant(continued) ▶Cobicistatis predicted to increase the exposure to fosaprepitant.oTheoretical ▶Fosaprepitantis predict ...

▶Antiepileptics(eslicarbazepine, oxcarbazepine)potentially decrease the exposure toglecaprevir. Avoid.rTheoretical ▶Antifungals, ...

Grapefruit juice(continued) ▶Grapefruit juiceis predicted to increase the exposure to lurasidone. Avoid.rTheoretical ▶Grapefruit ...

▶Monoamine-oxidase A and B inhibitors, irreversibleare predicted to decrease the antihypertensive effects of guanethidine. Avoid ...

H 2 receptor antagonists(continued) ▶H 2 receptor antagonistsare predicted to decrease the exposure toerlotinib.Erlotinibshould ...

▶HIV-protease inhibitorsare predicted to increase the exposure toalpha blockers(doxazosin).oStudy ▶HIV-protease inhibitorsmodera ...

HIV-protease inhibitors(continued) ▶Atazanavir(unboosted) increases the exposure tocombined hormonal contraceptives. Adjust dose ...

▶HIV-protease inhibitorsare predicted to increase the exposure tolapatinib. Avoid.oStudy→Also seeTABLE 9p. 849 ▶Ritonaviris pred ...

HIV-protease inhibitors(continued) ▶Darunavirincreases the risk of rash when given with raltegravir.oStudy ▶Fosamprenavir(booste ...

▶Aprepitantis predicted to decrease the effects ofhormone replacement therapy.oAnecdotal ▶Bosentanis predicted to decrease the e ...

Ibrutinib(continued) ▶St John’s Wortis predicted to decrease the exposure to ibrutinib. Avoid.rTheoretical Ibuprofen→see NSAIDs ...

▶Idelalisibis predicted to increase the exposure toguanfacine. Adjustguanfacinedose,p. 231.oStudy ▶Idelalisibis predicted to ver ...