BNF for Children (BNFC) 2018-2019

Pitolisant(continued) ▶Pitolisantis predicted to decrease the exposure toefavirenz. qTheoretical ▶Enzalutamideis predicted to mo ...

▶Grapefruit juiceis predicted to increase the exposure to praziquantel.oStudy ▶H 2 receptor antagonists(cimetidine)moderately in ...

Quetiapine(continued) ▶Antiarrhythmics(dronedarone)are predicted to increase the exposure toquetiapine. Avoid.oStudy ▶Antiepilep ...

Rabeprazole→see proton pump inhibitors Rabies vaccine ▶Antimalarials(chloroquine)decrease the efficacy ofrabies vaccine. Avoid.o ...

Reboxetine ▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital, phenytoin, primidone)are predicted to decrease the exposu ...

▶Idelalisibis predicted to increase the exposure toalitretinoin. Adjustalitretinoindose.oTheoretical ▶Macrolides(clarithromycin) ...

Rifabutin(continued) ▶Efavirenzslightly decreases the exposure torifabutin. Adjust dose.rStudy ▶Rifabutinis predicted to decreas ...

▶Rifampicinmoderately decreases the exposure tocabozantinib. Avoid.oStudy ▶Rifampicinis predicted to moderately increase the cle ...

Rifampicin(continued) ▶Rifampicinis predicted to decrease the efficacy of levonorgestrel. For FSRH guidance, seeContraceptives, ...

▶Rifampicinis predicted to decrease the exposure tosorafenib. oTheoretical ▶Rifampicinmarkedly decreases the exposure tostatins ...

Risperidone(continued) ▶Bupropionis predicted to increase the exposure torisperidone. Adjust dose.oStudy ▶Cinacalcetis predicted ...

Rufinamide→see antiepileptics Rupatadine→see antihistamines, non-sedating Ruxolitinib→seeTABLE 15p. 850 (myelosuppression) ▶Anti ...

Silver sulfadiazine PHARMACOLOGYSilver might inactivate enzymatic debriding agents—concurrent use might not be appropriate. Sime ...

▶Rifampicinis predicted to decrease the concentration of sirolimus. Avoid.rStudy ▶St John’s Wortis predicted to decrease the con ...

SSRIs(continued) fluvoxamine, paroxetine, sertraline).rTheoretical→Also see TABLE 9p. 849 ▶Fluvoxamineis predicted to increase t ...

▶SSRIs(fluoxetine, paroxetine)are predicted to moderately increase the exposure topitolisant. Use with caution and adjust dose.o ...

St John’sWort(continued) ▶St John’s Wortis predicted to decrease the concentration of elvitegravir. Avoid.rTheoretical ▶St John’ ...

▶St John’s Wortis predicted to decrease the exposure to velpatasvir. Avoid.oTheoretical ▶St John’s Wortis predicted to decrease ...

Statins(continued) ▶Fibrates(ciprofibrate)increase the risk of rhabdomyolysis when given withfluvastatin.rStudy ▶Fibrates(fenofi ...

▶Rifampicinvery markedly decreases the exposure to simvastatin.oStudy ▶Rolapitantis predicted to increase the exposure to rosuva ...