Science - USA (2021-07-09)

of progenitors but also highlights the inability of T21-FL GATA1s progenitor cells compared with LT-HSCs to initiate preleukemia ...

in secondary recipients (fig. S9, I and J). Taken together, our results, on the basis of the assess- ment of these defined HSPC ...

cells could be responsible for leukemic pro- gression, we sorted CD34+CD38+progenitor- enriched and CD34+CD38–stem cell–enriched ...

Wagenblastet al.,Science 373 , eabf6202 (2021) 9 July 2021 9 of 13 Control Chr21 miRNAs FSC-A SSC-A CD34-BV421 CD117-APC N-FL N- ...

CD117/KIT is a receptor tyrosine kinase that regulates HSC proliferation, maintenance, and survival after binding to its ligand, ...

of GATA1-binding sites at their promoters, and down-regulated pathways compared with T21 controls. Nevertheless, the addition of ...

of genetic drivers ( 61 )lendssupporttothe concept of convergence. Last, although our results demonstrate that Down syndrome leu ...

of HSC self-renewal and differentiation.Cell Stem Cell 25 , 682 – 696.e8 (2019). doi:10.1016/j.stem.2019.08.003; pmid: 31495782 ...

Science Webinars help youkeeppacewith emerging scientific fields! Stayinformedaboutscientificbreakthroughsanddiscoveries. Gainin ...

RESEARCH ARTICLE SUMMARY ◥ CORONAVIRUS Estimating infectiousness throughout SARS-CoV-2 infection course Terry C. Jones1,2,3†, Gu ...

RESEARCH ARTICLE ◥ CORONAVIRUS Estimating infectiousness throughout SARS-CoV-2 infection course Terry C. Jones1,2,3†, Guido Biel ...

had at least one positive RT-PCR test (Table 1). Positive subjects had a mean age of 51.7 years with high standard deviation (SD ...

977 non-B.1.1.7 cases using viral loads only from centers with B.1.1.7 and non-B.1.1.7 cases, andonlyfromthesamedayor1daybefore ...

results skews heavily toward older subjects, with very few below the age of 20 meeting the criterion (Fig. 4A). We estimated tim ...

course, the Hospitalized group has higher viral loads than the Other group, whose viral loads are in turn higher than those of t ...

where the viral loads fall on the viral load– culture probability curve. In our data, the viral loads involved in the difference ...

as influenza. However, it has become clear that there are important differences and uncertain- ties that would cast doubt on suc ...

and reviews of COVID-19 report mean incu- bation times of 4.8 to 6.7 days ( 4 , 39 – 44 ), which suggests that, on average, a pe ...

outcome, or indications for diagnostic test ap- plication, including symptomatic status, were not always available. In the absen ...

subjects whose full time series contains posi- tive RT-PCRs spread over a period exceeding 30 days. Such time series may be attr ...