Science - USA (2021-07-09)

superconductivity at low temperatures ( 50 ). Further experiments and accurate theories need to be developed to elucidate the ro ...

(Fig. 3). Reactants can be injected into the cavity and the products extracted for further analysis using standard equipment, su ...

ground-state chemistry. Strong coupling in general, but VSC in particular, is a new ap- proach to chemistry. VSC can also be use ...

by ultrafast microscopy.ACS Photonics 5 , 105–110 (2018). doi:10.1021/acsphotonics.7b01332 C. Gonzalez-Ballestero, J. Feist, E. ...

N. T. Phuc, P. Q. Trung, A. Ishizaki, Controlling the nonadiabatic electron-transfer reaction rate through molecular-vibration ...

READY TO PUT THE SPOTLIGHT ON YOUR RESEARCH? Submityourresearch: cts.ScienceMag.org ScienceImmunology.org Twitter: @SciImmunolog ...

RESEARCH ARTICLE SUMMARY ◥ CANCER Mapping the cellular origin and early evolution of leukemia in Down syndrome Elvin Wagenblast, ...

RESEARCH ARTICLE ◥ CANCER Mapping the cellular origin and early evolution of leukemia in Down syndrome Elvin Wagenblast^1 , Joan ...

(N-FL and T21-FL, respectively) obtained at 16 to 19 weeks of gestation and carried out phenotypic analysis of the HSPC hierarch ...

increase in expression upon differentiation commitment (fig. S2B). To examine the roles of GATA1s andSTAG2 in leukemogenesis ind ...

Last, T21-FL GATA1s grafts showed increased infiltration of myeloid lineage cells into the spleen compared with N-FL GATA1s (fig ...

T21-FL GATA1s grafts expressed the prim- itive stem cell markers CD34 and CD117 (KIT), megakaryocytic marker CD41, erythroid mar ...

of progenitors but also highlights the inability of T21-FL GATA1s progenitor cells compared with LT-HSCs to initiate preleukemia ...

in secondary recipients (fig. S9, I and J). Taken together, our results, on the basis of the assess- ment of these defined HSPC ...

cells could be responsible for leukemic pro- gression, we sorted CD34+CD38+progenitor- enriched and CD34+CD38–stem cell–enriched ...

Wagenblastet al.,Science 373 , eabf6202 (2021) 9 July 2021 9 of 13 Control Chr21 miRNAs FSC-A SSC-A CD34-BV421 CD117-APC N-FL N- ...

CD117/KIT is a receptor tyrosine kinase that regulates HSC proliferation, maintenance, and survival after binding to its ligand, ...

of GATA1-binding sites at their promoters, and down-regulated pathways compared with T21 controls. Nevertheless, the addition of ...

of genetic drivers ( 61 )lendssupporttothe concept of convergence. Last, although our results demonstrate that Down syndrome leu ...

of HSC self-renewal and differentiation.Cell Stem Cell 25 , 682 – 696.e8 (2019). doi:10.1016/j.stem.2019.08.003; pmid: 31495782 ...