Fundamentals of Medicinal Chemistry

10 18 19 20 21 22 23 25 26 27 28 29 31 32 30 24 1 2 3 4 5 6 7 8 12 13 15 14 17 16 11 9 C D A B (a) (Trans A/B ring junction ) (C ...

Consequently, their carbon skeletons usually contain five or multiples of five carbon atoms. The structures of terpenes may also ...

H OH CH H CH 3 H CH 3 CH 3 Menthol (counter-irritant) Eucalyptol O CH 3 CH 3 CH 3 Limonene (Lemon grass oil) Camphor CH 3 CH 3 C ...

Table 1.7 Examples of the classification ofa-phosphatidyl lipids. Common names are given in brackets R 2 Classification Glycerol ...

Table 1.8 (continued) Subclassification Structure Sulphatides (acidic glycolipids) have galactose residue with a sulphate group. ...

H CH 3 O N N O H N N H N NH 2 O N H O H HH OH H HOCH 2 OH N N N N NH 2 O H HH OH H HOCH 2 OH N N N O NH NH 2 Guanine (G) N N H N ...

O H HH H HO N N N N NH 2 O CH 2 OH P O O −O O P OH O− O H HH OH H N N N N NH 2 P O P O CH 2 O −O O −O P O O −O −O H O H HH OH H ...

Sugar Sugar Sugar O P O O P −O O O Sugar Sugar −O O Sugar C O P T O O G P −O O O −O O G A C Minor groove Major groove Major groo ...

AGGCAAT GC TA G A CGA TCC TTG G G G AT CT GC TA GGAA C CC T CCGTTAC G A T C G C T A G G A A CCC T A G C G AT C C TTGGG 3' end of ...

of bases that act as the code for the production of one specific peptide or protein molecule is known as a gene. Genes can norma ...

P O −O O N −O N N N N H H O H N O N Uracil residue Ribose residue Ribose residue Adenine residue (b) Anticodon A C 5' Terminal C ...

produced. These signals are in the form of specific sequences of bases. The RNA produced by transcription is known as either het ...

matter as the code for protein synthesis. mRNA is synthesized as required and, once its message has been delivered, it is eventu ...

(continued) (4) List fivegeneral classesof compound that are collectively known as lipids. Describe the essential differences be ...

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2 An Introduction to Drugs and their Action 2.1 Introduction The primary objective of medicinal chemistry is the design and disc ...

safe. All drugs can act as poisons if taken in excess. For example, overdoses of paracetamol can cause coma and death. Furthermo ...

required for the improvement in the treatment of existing diseases, the treatment of newly identified diseases and the productio ...

hence its effectiveness, in terms of its chemotherapeutic index, which he defined as chemotherapeutic index ¼ minimum curative d ...

Cimetidine Ranitidine (CH 3 ) 2 NCH 2 CH 2 SCH 2 CH 2 NHCNHCH 3 CHNO 2 O N CH 2 SCH 2 CH 2 NHCNHCH 3 NCN CH 3 N H An alternative ...