Science - USA (2021-10-29)
previously ( 5 , 6 , 86 , 90 ). Briefly, two lentiviral vector ISG libraries consisting of 539 human and 444 macaque ISGs were u ...
intensity projection images with pixel scal- ing of 0.04mm × 0.04mm each comprised a Z-stack of 10 individual slices with a tota ...
purified using MyONE silane beads (Life Tech- nology, 37002D). Adapters specific to each sample ( 35 ) were ligated to the cDNA ...
genome assembly quality. Regardless, the hits were excluded for completeness. The data and code used for this method are publicl ...
Western European ancestry from the CEPH collection). REFERENCESANDNOTES E. Pairo-Castineiraet al., Genetic mechanisms of critic ...
mBio 7 , e00258 (2016). doi:10.1128/mBio.00258-16; pmid: 27025250 S. K. Lauet al., Discovery of a novel coronavirus, China Ratt ...
M.N., M.L.T., C.L., V.H., J.A., I.J., N.C.R., M.V., R.M.P., J.Y.L., L.I., N.P., D.G.S., S.S., E.J.D.G., T.W.M.C., Q.G., E.L.D., ...
RESEARCH ARTICLES ◥ LIPID TRANSPORT Distinct allosteric mechanisms of first-generation MsbA inhibitors François A. Thélot1,2, We ...
stimulates MsbA ATPase activity despite abol- ishing LPS transport ( 28 ); the other group, here referred to as G compounds, blo ...
and unsharpened three-dimensional (3D) reconstructions (fig. S4B). This chain mis- match results in asymmetrical TMDs, with TMD1 ...
consensus map features a bent nanodisc, a sub- set of particles was incorporated in compar- atively flatter and larger nanodiscs ...
centralaxis(Fig.3C,bottom).TMD2thencol- lapses around TM6.A, with TM2.A moving closer to TM6.B. The convergence between TM2.A an ...
compared with that of the drug-free con- formation, CH1–CH2 distance is symmet- rically increased in the cryo-EM structures (fig ...
NUCLEAR ARCHITECTURE Single-cell nuclear architecture across cell types in the mouse brain Yodai Takei^1 , Shiwei Zheng^2 , Jina ...
SCIENCEscience.org 29 OCTOBER 2021¥VOL 374 ISSUE 6567 587 20 μm B 250 nm Chr4 Chr7 Chr2 A C D F Slc17a7 Csf1r Pvalb Mfge8 Sst Nd ...
as chromatin immunoprecipitation sequenc- ing (ChIP-seq) and split-pool recognition of interactions by tag extension (SPRITE) at ...
SCIENCEscience.org 29 OCTOBER 2021¥VOL 374 ISSUE 6567 589 A B Imaging loci in Chr10 (1-Mb resolution) # of genes Fraction of loc ...
gene densities and guanine-cytosine (GC) content, at 1-Mb resolution (Fig. 3C and figs. S9A and S12). However, some DNA loci are ...
Because proximal points have cell type– specific patterns for different chromatin marks across the genome, they can scaffold and ...
592 29 OCTOBER 2021¥VOL 374 ISSUE 6567 science.orgSCIENCE Boundary scorein each subcluster CTCF RAD21 Chr3 subcluster 7 Chr3 sub ...
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