Science - USA (2021-10-29)
SCIENCE science.org 29 OCTOBER 2021 • VOL 374 ISSUE 6567 576-B RESEARCH Edited by Michael Funk ALSO IN SCIENCE JOURNALS NEUROSCI ...
576-C 29 OCTOBER 2021 • VOL 374 ISSUE 6567 science.org SCIENCE RESEARCH | IN SCIENCE JOURNALS et al. developed mice with a condi ...
RESEARCH ARTICLE SUMMARY ◥ IMMUNOLOGY p21 produces a bioactive secretome that places stressed cells under immunosurveillance Ine ...
RESEARCH ARTICLE ◥ IMMUNOLOGY p21 produces a bioactive secretome that places stressed cells under immunosurveillance Ines Sturml ...
Rb appears to enhance the transcriptional activity of these TFs in SNCs to establish the PASP. Analysis of publicly available Rb ...
(fig. S8A). In a second migration assay, mac- rophage numbers selectively increased in the peritoneal lavage 4 days after intrap ...
injection of adeno-Cre virus. Hepatocytes with p21 overexpression (p21-OE) were cell-cycle arrested at d4 after injection and ex ...
revealed that coordinated induction of growth arrest and immunosurveillance is a distinctive feature of p21 (fig. S17 and table ...
senescence from d12 on (fig. S18, C to F). However, small clusters of Tom+KRASG12V hepatocytes were observed in d28 livers with ...
complementing established tumor-protective actions of immune cells based on the expres- sion of tumor-specific neoantigens ( 32 ...
The Myc-tagged humanKRASG12Vwas ampli- fied frompBABE-KRASG12V-puro (Addgene, 9052)andinsertedtotheMCS.Theresultant pBS31-CAG-L- ...
cultured in vascular cell basal medium (ATCC, PCS-100-030) supplemented with endothelial growth factors (Endothelial Cell Growth ...
L-KRASG12Vmice. These MEFs were infected withpTSIN-Cre-PGK-puro2lentivirus ( 43 ) to induce KRASG12Vexpression. These MEFs were ...
P-values for significance of differential expres- sion. Genes with FDR<0.05 were considered significantly differentially expr ...
rabbit anti-CD3e(Cell Signaling, #99940; 1:50), biotin-conjugated rabbit anti-CD4 (BioLegend, 100508, 1:50; in combination with ...
for 12 hours. Cells were counterstained with Hoechst and the percentage of SA-b-Gal+cells was then determined. At least 100 cell ...
anti-B220/CD45R (BD BioSciences; #553088; 1:100), and APC-conjugated anti-TCRb(BD BioSciences; #553174; 1:100). Cells were stain ...
F. Ramírezet al., deepTools2: A next generation web server for deep-sequencing data analysis.Nucleic Acids Res. 44 , W160–W165 ...
Where Science Gets Social. AAAS’ MemberCommunityisaone-stopdestinationforscientists and STEM enthusiasts alike. It’s“WhereScienc ...
RESEARCH ARTICLE SUMMARY ◥ INDIGENOUS PEOPLES Effects of land dispossession and forced migration on Indigenous peoples in North ...
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