Science - USA (2021-11-12)

injury, mice treated with the most bioactive coassembly showed a significant functional recovery (5.9 ± 0.5) compared with that ...

alkyltailwasmutatedfromV 2 A 2 to A 2 G 2 in the FGF2 PAs. Differences in dynamics between FGF2 PA molecules in the two coassemb ...

SCIENCEscience.org 12 NOVEMBER 2021¥VOL 374 ISSUE 6569 855 Fig. 6. Validating cell-signaling differences in vitro between two PA ...

Thus, the greater motion detected by NMR for FGF2 PA1 molecules must indicate freer translational motion of its clusters within ...

NEUROSCIENCE Stepwise synaptic plasticity events drive the early phase of memory consolidation Akihiro Goto1,2, Ayaka Bota1,2,3, ...

common downstream mediator ( 13 , 14 ), it was necessary to characterize the effects of CALI on LTD. However, we observed no eff ...

in the absence of illumination also formed a robust memory, ruling out the possibility that overexpression of CFL-SN contributes ...

to automatically determine the behavioral state of the animal ( 21 ), and CALI was trig- gered separately during either awake or ...

SCIENCEscience.org 12 NOVEMBER 2021¥VOL 374 ISSUE 6569 861 Fig. 4. Hippocampal online LTP and offline LTP have distinct roles in ...

accumulation (fig. S10, A and B). We then classified neurons in the noCALI group into two classes based on their participation i ...

ripples and cortical waves by electrical stimu- lation resulted in enhanced recall performance, whereas disruption of coupling r ...

crown surrounded by an electronegative belt (Fig. 1A). Consequently, halogen bonding is attributed to attractive electrostatic i ...

KPFM belongs to a family of SPM techniques that routinely provide real-space atomic reso- lution of surfaces. In the KPFM techni ...

enabled a direct mapping of the spatial charge distribution of thes-hole by means of the KPFM technique. Thus, it is instructive ...

molecules and Xe- and CO-tip models. Excel- lent agreement between thewB97X-V inter- action energies and the experimental data r ...

NEURODEGENERATION CD4 + T cells contribute to neurodegeneration in Lewy body dementia David Gate1,2,3, Emma Tapp2,3, Olivia Leve ...

clonally expanded (i.e., antigen-specific) cells were distinct in PD-DLB. To assess clonal ex- pansion, we performed single-cell ...

a marker of proinflammatory interleukin-17 (IL-17)–producing [T helper 17 (TH17)] mem- ory CD4+T cells ( 17 , 18 ) (Fig. 2F and ...

on PDD meninges, which revealed meningeal CD3+CXCR4+cells (fig. S7A). We noted locali- zation of the CXCR4 ligand, C-X-C motif c ...

1 (ACTG1) andactin beta(ACTB) (Fig. 5D), which regulate cytoskeletal control of antigen- dependent T cell activation ( 20 ). We ...