Science - USA (2021-11-12)

SCIENCE science.org 12 NOVEMBER 2021 • VOL 374 ISSUE 6569 837-C temperature as a diamond inclu- sion (see the Perspective by Fei ...

REVIEW SUMMARY ◥ NEURODEVELOPMENT Myelin: A gatekeeper of activity-dependent circuit plasticity? Giulia Bonetto, David Belin, Ra ...

REVIEW ◥ NEURODEVELOPMENT Myelin: A gatekeeper of activity-dependent circuit plasticity? Giulia Bonetto^1 , David Belin^2 , Ragn ...

along and between axons, so as to regulate the synchronization of inputs in neuronal circuits involving several brain regions by ...

oligodendrocyte lineage cells seems to be af- fected by neuronal activity ( 24 , 37 , 38 , 47 ), consistent with neuronal activi ...

Oligodendrogenesis dynamics in learning and memory Overall, the systematic assessment of oligo- dendrogenesis dynamics over the ...

region after learning the same skill ( 61 ). The delayed appearance of myelinating oligoden- drocytes indicates a pause in the c ...

In the white matter connecting these brain regions, oligodendrogenesis is, in contrast, only detected 4 weeks after learning. Ol ...

of learning and memory, a deeper knowl- edge of the functional role of myelin plasticity may unlock alternative therapeutic appr ...

Nat. Neurosci. 23 , 819–831 (2020). doi:10.1038/ s41593-020-0637-3; pmid: 32424285 S. O. Spitzeret al., Oligodendrocyte Progeni ...

RESEARCH ARTICLE SUMMARY ◥ DISEASE GENOMICS Mapping the proteo-genomic convergence of human diseases Maik Pietzner†, Eleanor Whe ...

RESEARCH ARTICLE ◥ DISEASE GENOMICS Mapping the proteo-genomic convergence of human diseases Maik Pietzner1,2†, Eleanor Wheeler^ ...

group ABO system transferase (ABO), key metabolic enzymes such as glucokinase reg- ulatory protein (GCKR), or lipid mediators su ...

variation to plasma concentrations (Fig. 2D, fig. S3, and table S3). For about one-third of the protein targets (n= 1249), >5 ...

subunit MIC10 (MOS1), far outperforming the contribution of the specific trans-pQTL rs398041972 (0.7%). rs398041972 resides abou ...

whole blood, we integrated gene expression data from the eQTLGen consortium ( 26 ), which confirmed 140 cis-eQTL/pQTL pairs and ...

neurotransmitters into the extracellular space ( 28 ); this locus was previously identified for Parkinson’s disease (table S5). ...

gene-protein convergence of diverse connec- tive tissue disorders as well as gene expression ofEFEMP1in subcutaneous adipose tis ...

knockout mice that display abnormal elastic fiber morphology, develop different types of hernias, and exhibit pelvic organ prola ...

and vagina (PP = 87.4%), and a possible role of the locus in puberty timing ( 58 , 59 ). We noted that most of the identified ci ...